The TRPV6 Calcium Channel and Its Relationship with Cancer

• Published in: Biology (Basel, Switzerland) Vol. 13; no. 3; p. 168
• Main Authors: Wang, Yifang, Deng, Xiaoling, Zhang, Rui, Lyu, Hao, Xiao, Shuai, Guo, Dong, Ali, Declan William, Michalak, Marek, Zhou, Cefan, Chen, Xing-Zhen, Tang, Jingfeng
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 05.03.2024; MDPI
• Subjects: Biological Sciences; Breast; breasts; calcium; Calcium channels; Calcium homeostasis; calcium signaling; Calcium signalling; Cancer; Cancer therapies; cancer therapy; Colon; digestive tract; Epithelium; Gastrointestinal tract; Homeostasis; kidneys; Mutation; Physiology; Prostate cancer; Review; Skin; Skin tests; Small intestine; Therapeutic targets; Thyroid; Transient receptor potential proteins; transient receptor potential vanilloid channels; TRP channels; TRPV6; cancer; TRPV6; TRP channels; calcium signaling
• ISSN: 2079-7737; 2079-7737
• DOI: 10.3390/biology13030168

Transient receptor potential vanilloid-6 (TRPV6) is a cation channel belonging to the TRP superfamily, specifically the vanilloid subfamily, and is the sixth member of this subfamily. Its presence in the body is primarily limited to the skin, ovaries, kidney, testes, and digestive tract epithelium. The body maintains calcium homeostasis using the TRPV6 channel, which has a greater calcium selectivity than the other TRP channels. Several pieces of evidence suggest that it is upregulated in the advanced stages of thyroid, ovarian, breast, colon, and prostate cancers. The function of TRPV6 in regulating calcium signaling in cancer will be covered in this review, along with its potential applications as a cancer treatment target.