Potential risk factors associated with diabetic mellitus in patients with Febrile upper urinary tract calculi with infection

• Published in: PloS one Vol. 20; no. 6; p. e0325724
• Main Authors: Xu, Meng, Xing, Shaoqiang, Zhang, Xuefeng, Jiang, Yongchao, Chen, Yun
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 27.06.2025; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Anti-Bacterial Agents - therapeutic use; Antibiotics; Bacteria; Calcification (ectopic); Calculi; Cerebrovascular diseases; Complications and side effects; Diabetes; Diabetes Complications; Diabetes mellitus; Diabetes Mellitus - epidemiology; Disease control; Drug resistance; Female; Fever; Fever - complications; Glucose; Health risks; Health services; Hospitalization; Hospitals; Humans; Hyperthermia; Intensive care; Kidney stones; Kidneys; Length of stay; Lithotripsy; Male; Metabolism; Middle Aged; Multidrug resistance; Nephrolithiasis; Patients; Procalcitonin; Regression analysis; Retrospective Studies; Risk Factors; Sepsis; Septic shock; Statistics; Surgery; Transplants & implants; Urinary Calculi - complications; Urinary tract; Urinary tract infections; Urinary Tract Infections - complications; Urinary Tract Infections - drug therapy; Urinary Tract Infections - epidemiology; Urine; Urogenital system; Vascular diseases; Vasoactive agents; China
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0325724

Patients with febrile upper urinary tract calculi with infection (FUUTCI) are prone to develop or have developed severe infection. This research aimed to evaluate the potential risk factors associated with diabetes mellitus (DM) in patients with FUUTCI. From September 2018 to December 2023, patients with FUUTCI admitted to our hospital were retrospectively studied. The patients were divided into a diabetic group (n=52) and a non-diabetic group (n=148), and the differences in demographics, etiology, infection indicators on admission, treatment, and outcome between the two groups were compared. Then regression analysis was performed for gender, stone location, occurrence of urinary sepsis, septic shock, use of pressors, bacterial multiresistance, positive fungal culture, and use of two or more antibiotics. Compared with non-diabetic patients (148 cases, 74.0%), diabetic patients (52 cases, 26.0%) had a higher prevalence of cardiovascular and cerebrovascular diseases (P=0.031), the rate of using two or more antibiotics (P=0.029), the positive rate of yeast culture (P=0.037), the procalcitonin value of admission or emergency (P=0.022). There was a significant difference in stone location (P=0.039). Regression analysis showed that DM was an independent risk factor for febrile urinary tract infection in patients with kidney stones compared to patients with ureteral stones (P=0.032). In patients with FUUTCI, the risk factors associated with DM made treatment more complicated. In patients with FUUTCI and under the premise of active treatments, DM was not a risk factor for urosepsis, septic shock, use of vasoactive drugs, and infection of multi-drug resistant bacteria. Compared to patients with ureteral calculi, DM was an independent risk factor for febrile urinary tract infection in patients with kidney calculi.