Probiotic supplementation and associated infant gut microbiome and health: a cautionary retrospective clinical comparison

• Published in: Scientific reports Vol. 8; no. 1; pp. 8283 - 16
• Main Authors: Quin, C., Estaki, M., Vollman, D. M., Barnett, J. A., Gill, S. K., Gibson, D. L.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.05.2018; Nature Publishing Group
• Subjects: 13/21; 45/91; 631/250; 692/4020; Acid production; Babies; Breast feeding; Breast milk; Breastfeeding & lactation; Digestive system; Fecal microflora; Feces; Humanities and Social Sciences; Infants; Intestinal microflora; Microbial activity; Microbiomes; Microbiota; Mucosa; multidisciplinary; Observational studies; Probiotics; Science; Science (multidisciplinary); Supplements
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-018-26423-3

While probiotics are a multi-billion dollar industry, there is little evidence to show that supplementing infants provides any health benefits. We conducted an observational study where 35 of 86 participating mothers self-administered probiotics during breastfeeding, as well as directly to their infants. The primary objective was to determine if probiotic exposure influenced the infants’ fecal microbiome while the secondary objective assessed associated changes to the mothers’ breast milk immunity and infant health. Analysis of infant fecal microbiome throughout the first 6 months of life revealed that probiotics were associated with higher abundances of Bifidobacterium at week 1 only. Short-chain fatty acid production and predicted metagenomic functions of the microbial communities were not altered. While probiotics did not alter breast milk immune markers, fecal sIgA responses were higher among probiotic supplemented infants. Surprisingly, this was not associated with better health outcomes, as the probiotic cohort had higher incidences of mucosal-associated illnesses as toddlers. This retrospective clinical comparison suggests that probiotic exposure during infancy has limited effects on gut microbial composition yet is associated with increased infection later in life. These correlative findings caution against probiotic supplementation during infancy until rigorous controlled follow-up studies determining their safety and efficacy have occurred.