Impact of difructose anhydride III, raffinose, and fructooligosaccharides on energy intake, gut hormones, and cecal fermentation in rats fed a high-fat and high-sucrose diet

We investigated the effects of dietary supplementation of difructose anhydride III (DFA III), raffinose (Raf), and fructooligosaccharides (FOS) on diet-induced obesity development. Male rats were fed normal or high-fat and high-sucrose (HFS) diet, with or without supplementing (3%) DFA III, Raf, or...

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Published inBioscience, biotechnology, and biochemistry Vol. 81; no. 11; pp. 2186 - 2194
Main Authors Hira, Tohru, Yanagihara, Kurumi, Koga, Toshiki, Takahashi, Keisuke, Nagura, Taizo, Uchino, Hirokatsu, Hara, Hiroshi
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 02.11.2017
Oxford University Press
Subjects
Animals
Cecum - drug effects
Cecum - metabolism
Cecum - microbiology
Diet, High-Fat - adverse effects
diet-induced obesity
Dietary Sucrose - adverse effects
difructose anhydride III
Disaccharides - pharmacology
Energy Intake - drug effects
Fermentation - drug effects
fructooligosaccharides
GLP-1
Hormones - metabolism
Male
Oligosaccharides - pharmacology
raffinose
Raffinose - pharmacology
Rats
Rats, Sprague-Dawley
difructose anhydride III
GLP-1
fructooligosaccharides
raffinose
diet-induced obesity
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Summary:We investigated the effects of dietary supplementation of difructose anhydride III (DFA III), raffinose (Raf), and fructooligosaccharides (FOS) on diet-induced obesity development. Male rats were fed normal or high-fat and high-sucrose (HFS) diet, with or without supplementing (3%) DFA III, Raf, or FOS, for 8 or 5 weeks. Supplementing DFA III to the HFS diet decreased energy intake compared to the non-supplemented HFS diet. Accordingly, body weight gain and fat accumulation reduced in DFA III-fed rats. Cecal acetate production and plasma glucagon-like peptide-1 (GLP-1) and peptide-YY (PYY) were elevated in DFA III-fed rats, while Raf and FOS partially affected these parameters. These results demonstrate that DFA III has suppressive effect on excessive energy intake driven by the palatable obesogenic diet, possibly due to combined effects of increased anorexigenic factors such as cecal acetate production and GLP-1/PYY secretion.
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ISSN:0916-8451
1347-6947
DOI:10.1080/09168451.2017.1373591