ABBA family of aromatic prenyltransferases: broadening natural product diversity

• Published in: Cellular and molecular life sciences : CMLS Vol. 65; no. 10; pp. 1459 - 1463
• Main Authors: Tello, M, Kuzuyama, T, Heide, L, Noel, J. P, Richard, S. B
• Format: Journal Article
• Language: English
• Published: Basel Basel : SP Birkhäuser Verlag Basel 01.05.2008; SP Birkhäuser Verlag Basel; Springer Nature B.V
• Subjects: Amino Acids, Aromatic - metabolism; antibacterial; Aromatic; Bacterial Proteins - metabolism; Bacterial Proteins - physiology; Biochemistry; Biodiversity; Biological Products - physiology; Biomedical and Life Sciences; Biomedicine; Biosynthesis; Biotechnology; Cell Biology; chemoprotection; Dimethylallyltranstransferase - chemistry; Dimethylallyltranstransferase - metabolism; Dimethylallyltranstransferase - physiology; Enzymes; isoprenoids; Life Sciences; Models, Biological; Models, Molecular; Multigene Family; Natural products; Pharmacology; Phylogeny; prenyltransferase; Protein Conformation; Protein Engineering - methods; PT-barrel; regio-selective; Substrates; Visions & Reflections (Minireview); natural products; isoprenoids; Aromatic; PT-barrel; antibacterial; regio-selective; prenyltransferase; chemoprotection
• ISSN: 1420-682X; 1420-9071
• DOI: 10.1007/s00018-008-7579-3

An analysis of the ABBA family of aromatic prenyltransferases was conducted. further structural and biochemical characterization of additional members of the ABBA family of aromatic PTases, such as the novel fungal members, will afford a more complete understanding of the key features involved in substrate selection and specificity/promiscuity.