Association of Mycobacterium tuberculosis Beijing genotype with tuberculosis relapse in Singapore

• Published in: Epidemiology and infection Vol. 134; no. 2; pp. 329 - 332
• Main Authors: SUN, Y.-J., LEE, A. S. G., WONG, S.-Y., PATON, N. I.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.04.2006
• Subjects: Adolescent; Adult; Age; Aged; Aged, 80 and over; Bacterial diseases; Biological and medical sciences; Child; Drug resistance; Ethnicity; Female; Fundamental and applied biological sciences. Psychology; Genotype; Genotype & phenotype; Genotypes; Hospitals; Human bacterial diseases; Humans; Infections; Infectious diseases; Logistic regression; Male; Medical sciences; Microbiology; Middle Aged; Mycobacterium tuberculosis; Mycobacterium tuberculosis - genetics; Mycobacterium tuberculosis - pathogenicity; Odds Ratio; Operating rooms; Patients; Polymorphism; Recurrence; Regression analysis; Relapse; Short Report; Short Reports; Singapore - epidemiology; Tuberculosis; Tuberculosis and atypical mycobacterial infections; Tuberculosis, Pulmonary - genetics; Tuberculosis, Pulmonary - pathology; Asia; Singapore; Beijing China; Vietnam; China; Human; Microbiology; Genotype; Mycobacterial infection; Epidemiology; Infection; Tuberculosis; Mycobacterium tuberculosis; Mycobacteriales; Bacteriosis; Mycobacteriaceae; Bacteria; Actinomycetes
• ISSN: 0950-2688; 1469-4409
• DOI: 10.1017/S095026880500525X

The relationship of Mycobacterium tuberculosis Beijing genotype with tuberculosis relapse was examined. Beijing strains were detected from 32 out of 45 (71%) relapsed cases and 148 out of 290 (51%) non-relapsed cases. Multivariate logistic regression analysis revealed that Beijing genotype was significantly associated with tuberculosis relapse (OR 2·64, 95% CI 1·30–5·34, P=0·005).