Histopathology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

Abstract Nonalcoholic fatty liver disease (NAFLD) is the liver injury most often associated with disorders of insulin resistance, including obesity, diabetes and the metabolic syndrome. The term encompasses several patterns of liver injury, including a relatively benign condition of steatosis withou...

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Published inMetabolism, clinical and experimental Vol. 65; no. 8; pp. 1080 - 1086
Main Authors Brown, Gregory Thomas, Kleiner, David E
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.08.2016
Subjects
Biopsy
Endocrinology & Metabolism
Fatty Liver - complications
Fatty Liver - pathology
Histology
Humans
Liver - pathology
Liver biopsy
Metabolic Syndrome - complications
Metabolic Syndrome - pathology
Non-alcoholic Fatty Liver Disease - complications
Non-alcoholic Fatty Liver Disease - pathology
Steatohepatitis
Steatosis
Liver biopsy
Histology
Steatohepatitis
Steatosis
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Summary:Abstract Nonalcoholic fatty liver disease (NAFLD) is the liver injury most often associated with disorders of insulin resistance, including obesity, diabetes and the metabolic syndrome. The term encompasses several patterns of liver injury, including a relatively benign condition of steatosis without hepatocellular injury, nonalcoholic steatohepatitis (NASH), and a pattern of zone 1 steatosis, inflammation and fibrosis mainly observed in prepubertal children. Staging and grading systems have been developed to characterize the histological changes in NAFLD, mainly as a tool for clinical research. The histological features of NAFLD across these different manifestations and the scoring systems used to evaluate disease severity are discussed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0026-0495
1532-8600
DOI:10.1016/j.metabol.2015.11.008