Prognostic impact of COX-2 in non-small cell lung cancer: A comprehensive compartment-specific evaluation of tumor and stromal cell expression

• Published in: Cancer letters Vol. 356; no. 2; pp. 837 - 845
• Main Authors: Mattsson, Johanna S.M, Bergman, Bengt, Grinberg, Marianna, Edlund, Karolina, Marincevic, Millaray, Jirström, Karin, Pontén, Fredrik, Hengstler, Jan G, Rahnenführer, Jörg, Karlsson, Mats G, Karlsson, Christina, Helenius, Gisela, Botling, Johan, Micke, Patrick, Gulyas, Miklos
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 28.01.2015; Elsevier Limited
• Subjects: Adenocarcinoma - metabolism; Adenocarcinoma - mortality; Adenocarcinoma - pathology; Age; Aged; Biomarkers, Tumor - metabolism; Cancer and Oncology; Cancer och onkologi; Carcinoma, Large Cell - metabolism; Carcinoma, Large Cell - mortality; Carcinoma, Large Cell - pathology; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - mortality; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; Clinical Medicine; Cohort Studies; Cyclooxygenase 2; Cyclooxygenase 2 - genetics; Cyclooxygenase 2 - metabolism; Female; Gene expression; Hematology, Oncology and Palliative Medicine; Humans; Immunoenzyme Techniques; Immunohistochemistry; In Situ Hybridization; Klinisk medicin; Lung cancer; Lung Neoplasms - metabolism; Lung Neoplasms - mortality; Lung Neoplasms - pathology; Male; Medical and Health Sciences; Medical prognosis; Medicin och hälsovetenskap; Microarray; Oncology; Onkologi; Pathology; Patients; Patologi; Prognosis; Protein expression; Proteins; PTGS2; Real-Time Polymerase Chain Reaction; Regression analysis; Reverse Transcriptase Polymerase Chain Reaction; Review boards; RNA, Messenger - genetics; Rodents; Stromal Cells - metabolism; Stromal Cells - pathology; Immunohistochemistry; Prognosis; PTGS2; Microarray; Cyclooxygenase 2; Lung cancer
• ISSN: 0304-3835; 1872-7980; 1872-7980
• DOI: 10.1016/j.canlet.2014.10.032

Highlights • COX-2 is frequently compartment specific expressed in human non-small cell lung. • COX-2 expression in tumor cells is not associated with prognosis. • COX-2 expression in stromal cells may have a prognostic impact.