Long Non-Coding RNA SNHG14 Impedes Viability, Migration and Invasion of Endometrial Carcinoma Cells Through Modulating miR-93-5p/ ZBTB7A Axis

• Published in: Cancer management and research Vol. 12; pp. 9515 - 9525
• Main Authors: Zhang, Kai, Cai, Yongqin, Zhou, Qi, Sun, Hong, Wei, Jinying
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2020; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: Analysis; Biomarkers; Biotechnology; Breast cancer; Cancer genetics; Cancer metastasis; Carcinoma; Endometrial cancer; endometrial carcinoma; Gastric cancer; Genes; Genetic aspects; Genomics; Immunotherapy; invasion; Kinases; Metastasis; migration; mir-93-5p; Original Research; Patients; Proteins; RNA; RNA polymerase; snhg14; Software; Stem cells; Tumorigenesis; Wound care; Wound healing; zbtb7a; Japan; China; United States > US; migration; SNHG14; endometrial carcinoma; invasion; miR-93-5p; ZBTB7A
• ISSN: 1179-1322; 1179-1322
• DOI: 10.2147/CMAR.S257419

The function of long non-coding RNA small nucleolar RNA host gene 14 (SNHG14) in endometrial carcinoma (EC) has not been thoroughly reported. This research is designed to research the action mechanism of SNHG14 in EC development. The expression of SNHG14 was estimated in The Cancer Genome Atlas and was verified by qRT-PCR in EC tissues. The correlation between SNHG14 expression and clinicopathological features of EC patients was analyzed. Cell viability, wound healing rate, and relative invasion rate were examined by MTT, wound healing, and transwell assay. StarBase, TargetScan, RNA pull-down, and dual luciferase reporter gene (DLR) assay were conducted to analyze the relationship among SNHG14, miR-93-5p and . SNHG14 was underexpressed in EC. SNHG14 expression was significantly relevant to menstruation, FIGO stage, histological grade and lymphatic metastasis of EC patients. SNHG14 overexpression hampered viability, migration and invasion of EC cells. SNHG14 functioned as a sponge for miR-93-5p, and miR-93-5p inhibition restrained cell viability, migration and invasion in EC. In addition, miR-93-5p directly targeted to , which was underexpressed in EC. The suppressive action of SNHG14 overexpression on the viability, migration and invasion of EC cells was partly rescued by miR-93-5p overexpression or silencing. LncRNA SNHG14 hampered the viability, migration and invasion of EC cells via modulating miR-93-5p/ axis.