Plasma soluble P-selectin correlates with triglycerides and nitrite in overweight/obese patients with schizophrenia

• Published in: Pteridines Vol. 31; no. 1; pp. 61 - 67
• Main Authors: Bourassa, Katelynn A., Postolache, Teodor T., Dagdag, Aline, Fuchs, Dietmar, Okusaga, Olaoluwa O.
• Format: Journal Article
• Language: English
• Published: England De Gruyter Open 01.01.2020; Walter de Gruyter GmbH; De Gruyter
• Subjects: Adults; atherosclerosis; Biomarkers; Body size; Correlation analysis; Correlation coefficients; Evaluation; Health risk assessment; Heart diseases; Lipids; Mathematical analysis; nitrite; Nitrogen dioxide; Obesity; Overweight; overweight/obesity; P-selectin; Risk analysis; Schizophrenia; Triglycerides; Weight; atherosclerosis; nitrite; schizophrenia; P-selectin; overweight/obesity
• ISSN: 0933-4807; 2195-4720
• DOI: 10.1515/pteridines-2020-0012

Soluble P-selectin (sP-selectin) is associated with risk factors for cardiovascular disease (CVD) but this association has not been evaluated in patients with schizophrenia. This study primarily evaluated the association of sP-selectin with plasma lipids and nitrite (NO -) respectively in overweight/obese adults with schizophrenia. One-hundred and six patients with schizophrenia (mean age 32.9 years; 71.60% male) were recruited from a psychiatric hospital. Participants completed a structured interview and provided a fasting blood sample. Body mass index (BMI) was used to divide the sample into normal weight and overweight/obese groups. Pearson’s and partial correlation coefficients (controlling for age, sex, race, education, and inflammation) were calculated to examine the association of sP-selectin with plasma lipids, and NO - in the overweight/obese patients (primary analysis), as well as in the normal weight patients and the total sample (exploratory analyses). After controlling for potential confounders, sP-selectin positively correlated with triglycerides ( = 0.38, = 0.01) and NO - ( = 0.40, < 0.01) in the overweight/ obese group only. : Future longitudinal studies should evaluate the utility of sP-selectin as a biomarker of CVD in overweight/obese adults with schizophrenia (for example, by relating sP-selectin to incidence of cardiovascular events).