Microsomic and macrosomic body structure in children and adolescents affected by syndromes or diseases associated with neurodysfunction

• Published in: Scientific reports Vol. 11; no. 1; pp. 6349 - 14
• Main Authors: Perenc, Lidia, Guzik, Agnieszka, Podgórska-Bednarz, Justyna, Drużbicki, Mariusz
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.03.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 692/617/375/2764; 692/617/375/366; Adolescent; Adolescents; Body Height; Body Mass Index; Body Weight; Cephalometry; Child; Child, Preschool; Children; Congenital diseases; Female; Fetal Growth Retardation - epidemiology; Fetal Growth Retardation - physiopathology; Hemiplegia; Humanities and Social Sciences; Humans; Hydrocephalus; Male; multidisciplinary; Nervous system; Neurodevelopmental Disorders - epidemiology; Neurodevelopmental Disorders - genetics; Neurological diseases; Obesity - epidemiology; Obesity - physiopathology; Paralysis; Poland - epidemiology; Rehabilitation; Retrospective Studies; Science; Science (multidisciplinary); Spasticity; Statistical analysis; Teenagers; Poland
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-85587-7

In Poland the issue of microsomic body structure (micro-SBS) and macrosomic body structure (macro-SBS) has so far been overlooked. Up until now only a small amount of data have been published, most often as an overview of the problem. The current study was designed to investigate the co-occurrence of microsomic/macrosomic body structure (micro/macro-SBS) and congenital nervous system disorders or neurological syndromes with symptoms visible from infancy, based on essential data acquired during admission procedures at a neurological rehabilitation ward for children and adolescents. The study applied a retrospective analysis of data collected during hospitalization of 327 children and adolescents, aged 4–18 years who had been affected since infancy by congenital disorders of the nervous system and/or neurological syndromes associated with a minimum of one neurodysfunction. To identify subjects with microsomic or macrosomic body structure in the group of children and adolescents, the adopted criteria took into account z-score values for body height (z-score Ht), body weight (z-score Wt), head circumference (z-score HC), BMI (z-score BMI) and head circumference index (z-score HCI). The rates of micro/macro-SBS in the study group amounted to 7.3% and 0.6%, respectively. The findings show a more frequent co-occurrence of, as well as statistically significant correlations between, micro/macro-SBS and type of spasticity (cerebral palsy) (p = 0.024) as well as hydrocephalus not treated surgically (p < 0.001). Macro-SBS was found to more frequently co-occur with hemiplegia and hydrocephalus not treated surgically.