Down-Regulation of Intestinal Multidrug Resistance-Associated Protein 2 in Long-Evans Cinnamon Rats

• Published in: DRUG METABOLISM AND PHARMACOKINETICS Vol. 22; no. 6; pp. 450 - 455
• Main Authors: Chiba, Makoto, Itagaki, Shirou, Kobayashi, Masaki, Hirano, Takeshi, Iseki, Ken
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2007; Japanese Society for the Study of Xenobiotics
• Subjects: ABC transporter; Animals; ATP-Binding Cassette Transporters - antagonists & inhibitors; ATP-Binding Cassette Transporters - genetics; ATP-Binding Cassette Transporters - metabolism; Disease Models, Animal; Down-Regulation; Hepatolenticular Degeneration - metabolism; Jejunum - drug effects; Jejunum - metabolism; LEC rats; Male; Mannitol - metabolism; Mrp2; Pravastatin - metabolism; Probenecid - pharmacology; Rats; Rats, Inbred LEC; Rats, Wistar; RNA, Messenger - analysis; Species Specificity; Sulfobromophthalein - pharmacology; Wilson's disease; LEC rats; Mrp2; ABC transporter; Wilson's disease
• ISSN: 1347-4367; 1880-0920
• DOI: 10.2133/dmpk.22.450

Wilson's disease is an inherited, autosomal recessive disorder of copper accumulation and toxicity. Lifelong chelation therapy is essential in all Wilson's disease patients. Intestinal absorption of some compounds is limited partly because they are preferentially transported in the secretory direction. Several ATP-binding cassette (ABC) transporters are expressed in the apical membrane of the small intestine and secrete various drugs into the lumen. In this study, we investigated the characteristics of the intestinal efflux ABC transporters in LEC rats. We found that the expression of multidrug resistance-associated protein 2 (Mrp2) in the jejunum of Long-Evans Cinnamon (LEC) rats, an animal model for Wilson's disease, is decreased.