Effect of autoimmune thyroid disease in older euthyroid infertile woman during the first 35 days of an IVF cycle

• Published in: Fertility and sterility Vol. 95; no. 3; pp. 1178 - 1181
• Main Authors: Reh, Andrea, M.D, Chaudhry, Sonal, M.D, Mendelsohn, Felicia, M.D, Im, Shelly, M.D, Rolnitzky, Linda, M.S, Amarosa, Alana, M.D, Levitz, Mortimer, Ph.D, Srinivasa, Suman, M.D, Krey, Lewis, Ph.D, Berkeley, Alan S., M.D, Grifo, James A., M.D., Ph.D, Danoff, Ann, M.D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.03.2011; Elsevier
• Subjects: abortion (animals); Abortion, Spontaneous - epidemiology; Adult; Biological and medical sciences; blood serum; Case-Control Studies; Diseases of mother, fetus and pregnancy; Endocrinopathies; Female; Fertilization in Vitro - statistics & numerical data; Gynecology. Andrology. Obstetrics; Humans; hypothyroidism; Hypothyroidism - epidemiology; in vitro fertilization; infertility; Infertility, Female - epidemiology; Infertility, Female - therapy; Internal Medicine; IVF; Maternal Age; Medical sciences; miscarriage; Non tumoral diseases. Target tissue resistance. Benign neoplasms; Obstetrics and Gynecology; patients; Pregnancy; pregnancy outcome; Pregnancy Outcome - epidemiology; Pregnancy. Fetus. Placenta; Prevalence; subclinical hypothyroidism; thyroglobulin antibody; Thyroid autoimmunity; thyroid function; Thyroid Gland - physiology; thyroid peroxidase antibody; Thyroid. Thyroid axis (diseases); Thyroiditis, Autoimmune - epidemiology; thyrotropin; women; Thyroid autoimmunity; thyroglobulin antibody; hypothyroidism; miscarriage; thyroid peroxidase antibody; IVF; subclinical hypothyroidism; infertility; Endocrinopathy; Autoimmunity; Pregnancy disorders; Autoimmune disease; Asymptomatic; Thyroid gland; Abortion; Peroxidase; Immunopathology; Enzyme; Antibody; Gynecology; Thyroid diseases; Female sterility; Hypothyroidism; Obstetrics; In vitro fertilization embryo transfer; Peroxidases; Thyroglobulin; Thyroid hormone; Oxidoreductases
• ISSN: 0015-0282; 1556-5653
• DOI: 10.1016/j.fertnstert.2010.09.053

In this case-control study of euthyroid first-cycle IVF patients ≥38 years old with singleton baby, miscarriage, biochemical pregnancy, and no pregnancy outcomes from 2005–2008, we assayed frozen serum for autoimmune thyroid disease (AITD) and thyroid function at cycle start, trigger, and 4 and 5 weeks’ gestation. AITD prevalence in older infertile women was similar across clinical outcomes, and although AITD was associated with a higher baseline TSH, TSH remained within acceptable ranges, suggesting that T4 supplementation may not affect maternal outcomes in older euthyroid AITD patients through 5 weeks gestation.