N-Heterocyclic-Carbene-Catalyzed Domino Reactions via Two or More Activation Modes

Organocatalytic domino processes have become a rapidly growing area of research. N-heterocyclic carbenes (NHCs) have emerged as powerful organocatalysts for various transformations and continue to have widespread application. In the last decade, domino reactions catalyzed by NHCs have seen significa...

Full description

Saved in:
Bibliographic Details
Published iniScience Vol. 2; pp. 1 - 26
Main Authors Chen, Xiang-Yu, Li, Sun, Vetica, Fabrizio, Kumar, Mukesh, Enders, Dieter
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 27.04.2018
Elsevier
Subjects
Organic Chemistry Methods
Organic Synthesis
Review
Stereochemistry
Organic Synthesis
Organic Chemistry Methods
Stereochemistry
Online AccessGet full text

Cover

More Information
Summary:Organocatalytic domino processes have become a rapidly growing area of research. N-heterocyclic carbenes (NHCs) have emerged as powerful organocatalysts for various transformations and continue to have widespread application. In the last decade, domino reactions catalyzed by NHCs have seen significant progress since the different activation modes could be successfully combined in one process. The most attractive features of these domino sequences include the readily available catalysts and substrates, the simple operational procedures, and the rapid assembly of complex molecular scaffolds with excellent levels of stereocontrol under mild reaction conditions. This review covers the advances in NHC-catalyzed domino reactions by focusing on the reaction scope, limitations, and mechanism with a close attention to the features of the reaction substrates. [Display omitted] Organic Synthesis; Stereochemistry; Organic Chemistry Methods
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:2589-0042
2589-0042
DOI:10.1016/j.isci.2018.03.006