Physical Properties of an Ionic Liquid Composed of Two Water-Soluble Vitamins and Enhanced Skin Permeation of Both Vitamins

A highly viscous substance was prepared by evaporating an ethanol solution containing two hydrophilic vitamins; vitamin C, and vitamin B6. The viscous substance and physical mixture of the two vitamins were tested using a differential scanning calorimeter and an X-ray diffractometer. The highly visc...

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Published inPharmaceutics Vol. 12; no. 5; p. 427
Main Authors Sugibayashi, Kenji, Yoshida, Yuya, Suzuki, Ryuichiro, Yoshizawa, Kota, Mori, Kenji, Itakura, Shoko, Takayama, Kozo, Todo, Hiroaki
Format Journal Article
LanguageEnglish
Published Switzerland MDPI 06.05.2020
MDPI AG
Subjects
liquid crystal
skin permeation
solubility
vitamin B6
vitamin C
vitamin B6
skin permeation
solubility
vitamin C
liquid crystal
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Summary:A highly viscous substance was prepared by evaporating an ethanol solution containing two hydrophilic vitamins; vitamin C, and vitamin B6. The viscous substance and physical mixture of the two vitamins were tested using a differential scanning calorimeter and an X-ray diffractometer. The highly viscous substance was found to be a liquid crystal (LC) made of these two hydrophilic vitamins. Determination by proton nuclear magnetic resonance measurement suggested that intramolecular hydrogen bonding in vitamin B6 was eliminated by the LC formation. This LC compound showed high solubility in 1,3-butanediol (almost 87%). Much higher skin permeation of both vitamin C and B6 was also observed from the LC compound than that from the physical mixture. The present LC compound containing vitamin C and vitamin B6 may be useful for pharmaceutical and cosmeceutical applications.
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ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics12050427