The Role of Post-Translational Modifications in the Phase Transitions of Intrinsically Disordered Proteins

• Published in: International journal of molecular sciences Vol. 20; no. 21; p. 5501
• Main Authors: Owen, Izzy, Shewmaker, Frank
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 05.11.2019; MDPI
• Subjects: Amino acids; Animals; Humans; Intrinsically Disordered Proteins - chemistry; Intrinsically Disordered Proteins - metabolism; intrinsically disordered regions; Liquid phases; liquid–liquid phase separation; Macromolecules; Measles; membraneless organelles; Mutation; Neurodegenerative Diseases - metabolism; Phase separation; Phase Transition; Phase transitions; Phosphorylation; Post-translation; post-translational modifications; Protein Domains; Protein Processing, Post-Translational; Proteins; Proteomes; Proteomics; Review; Translation; membraneless organelles; post-translational modifications; liquid–liquid phase separation; intrinsically disordered regions
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms20215501

Advances in genomics and proteomics have revealed eukaryotic proteomes to be highly abundant in intrinsically disordered proteins that are susceptible to diverse post-translational modifications. Intrinsically disordered regions are critical to the liquid-liquid phase separation that facilitates specialized cellular functions. Here, we discuss how post-translational modifications of intrinsically disordered protein segments can regulate the molecular condensation of macromolecules into functional phase-separated complexes.