Adult-onset Still's Disease with Acute Kidney Injury Requiring Hemodialysis: A Case Report and Literature Review

Adult-onset Still's disease (AOSD) is characterized by high spiking fever, evanescent rash, and arthritis. However, AOSD rarely presents with severe acute kidney injury (AKI). We herein present the case of a 56-year-old woman with new-onset AOSD who rapidly developed AKI. A physical examination...

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Published inInternal Medicine Vol. 62; no. 19; pp. 2901 - 2906
Main Authors Saito, Kenji, Temmoku, Jumpei, Sumichika, Yuya, Yoshida, Shuhei, Takano, Eisuke, Watanabe, Shuhei, Matsumoto, Haruki, Fujita, Yuya, Matsuoka, Naoki, Asano, Tomoyuki, Sato, Shuzo, Watanabe, Hiroshi, Migita, Kiyoshi
Format Journal Article
LanguageEnglish
Published Japan The Japanese Society of Internal Medicine 01.10.2023
Japan Science and Technology Agency
Subjects
acute kidney injury
Adult-onset Still's disease
Case Report
Cell activation
Exanthema
Fever
Hemodialysis
Internal medicine
Juvenile rheumatoid arthritis
Kidneys
Literature reviews
Macrophages
Steroid hormones
Thrombocytopenia
hemodialysis
Adult-onset Still's disease
acute kidney injury
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Summary:Adult-onset Still's disease (AOSD) is characterized by high spiking fever, evanescent rash, and arthritis. However, AOSD rarely presents with severe acute kidney injury (AKI). We herein present the case of a 56-year-old woman with new-onset AOSD who rapidly developed AKI. A physical examination and laboratory data revealed spiking fever, evanescent rash, thrombocytopenia, hyperferritinemia, and azotemia. The patient was diagnosed with AOSD complicated by AKI and macrophage activation syndrome. Treatment with high-dose steroids, hemodialysis, and plasma exchange successfully resolved her AKI. In this report, we review previously published reports on AOSD accompanied by AKI and discuss this rare complication in AOSD.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Review-3
content type line 23
ObjectType-Feature-5
ObjectType-Article-4
ObjectType-Report-1
Correspondence to Jumpei Temmoku, temmoku@fmu.ac.jp
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.1026-22