Interactions between sleep, stress, and metabolism: From physiological to pathological conditions

Poor sleep quality due to sleep disorders and sleep loss is highly prevalent in the modern society. Underlying mechanisms show that stress is involved in the relationship between sleep and metabolism through hypothalamic-pituitary-adrenal (HPA) axis activation. Sleep deprivation and sleep disorders...

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Bibliographic Details
Published inSleep science (Sao Paulo, Brazil) Vol. 8; no. 3; pp. 143 - 152
Main Authors Hirotsu, Camila, Tufik, Sergio, Andersen, Monica Levy
Format Journal Article
LanguageEnglish
Published Brazil Elsevier 01.11.2015
Thieme Revinter Publicações Ltda
Subjects
Cortisol
Hypothalamic–pituitary–adrenal axis
Metabolism
Obesity
Review
Sleep
Stress
Obesity
Cortisol
Sleep
Metabolism
Hypothalamic–pituitary–adrenal axis
Stress
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Summary:Poor sleep quality due to sleep disorders and sleep loss is highly prevalent in the modern society. Underlying mechanisms show that stress is involved in the relationship between sleep and metabolism through hypothalamic-pituitary-adrenal (HPA) axis activation. Sleep deprivation and sleep disorders are associated with maladaptive changes in the HPA axis, leading to neuroendocrine dysregulation. Excess of glucocorticoids increase glucose and insulin and decrease adiponectin levels. Thus, this review provides overall view of the relationship between sleep, stress, and metabolism from basic physiology to pathological conditions, highlighting effective treatments for metabolic disturbances.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1984-0659
1984-0063
1984-0063
DOI:10.1016/j.slsci.2015.09.002