Bioactive flavonoids in medicinal plants: Structure, activity and biological fate

Flavonoids, a class of polyphenol secondary metabolites, are presented broadly in plants and diets. They are believed to have various bioactive effects including anti-viral, anti-inflammatory, cardioprotective, anti-diabetic, anti-cancer, anti-aging, etc. Their basic structures consist of C6C3C6 rin...

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Published inAsian journal of pharmceutical sciences Vol. 13; no. 1; pp. 12 - 23
Main Authors Wang, Tian-yang, Li, Qing, Bi, Kai-shun
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.01.2018
Shenyang Pharmaceutical University
Elsevier
Subjects
Activity
Bioavailability
Flavonoid
Pharmacokinetics
Review
Structure
Activity
Bioavailability
Structure
Pharmacokinetics
Flavonoid
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Summary:Flavonoids, a class of polyphenol secondary metabolites, are presented broadly in plants and diets. They are believed to have various bioactive effects including anti-viral, anti-inflammatory, cardioprotective, anti-diabetic, anti-cancer, anti-aging, etc. Their basic structures consist of C6C3C6 rings with different substitution patterns to produce a series of subclass compounds, and correlations between chemical structures and bioactivities have been studied before. Given their poor bioavailability, however, information about associations between structure and biological fate is limited and urgently needed. This review therefore attempts to bring some order into relationships between structure, activity as well as pharmacokinetics of bioactive flavonoids.
ISSN:1818-0876
2221-285X
DOI:10.1016/j.ajps.2017.08.004