Role of Radiology in the Preoperative Detection of Arterial Calcification and Celiac Trunk Stenosis and Its Association with Anastomotic Leakage Post Esophagectomy, an Up-to-Date Review of the Literature

• Published in: Cancers Vol. 14; no. 4; p. 1016
• Main Authors: Tzortzakakis, Antonios, Kalarakis, Georgios, Huang, Biying, Terezaki, Eleni, Koltsakis, Emmanouil, Kechagias, Aristotelis, Tsekrekos, Andrianos, Rouvelas, Ioannis
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17.02.2022; MDPI
• Subjects: Abdomen; Anastomotic leak; Aorta; arterial calcification; Arteries; Arteriosclerosis; Calcification; Calcification (ectopic); Cancer therapies; Computed tomography; Coronary vessels; Endoscopy; Esophageal cancer; esophagectomy; Esophagus; Literature reviews; Medical imaging; Medicin och hälsovetenskap; Mortality; Patients; Plaques; Quality of life; Radiology; Risk factors; Stenosis; Systematic Review; Veins & arteries; computed tomography; risk factors; esophageal cancer; anastomotic leak; arterial calcification; esophagectomy; celiac trunk stenosis
• ISSN: 2072-6694; 2072-6694
• DOI: 10.3390/cancers14041016

Surgical resection of the esophagus remains a critical component of the multimodal treatment of esophageal cancer. Anastomotic leakage (AL) is the most significant complication following esophagectomy, in terms of clinical implications. Identifying risk factors for AL is important for modifying patient management and improving surgical outcomes. This review aims to examine the role of radiological risk factors for AL after esophagectomy, and in particular, arterial calcification and celiac trunk stenosis. Eligible publications prior to 25 August 2021 were retrieved from Medline and Google Scholar using a predefined search algorithm. A total of 68 publications were identified, of which 9 original studies remained for in-depth analysis. The majority of these studies found correlations between calcifications in the aorta, celiac trunk, and right post-celiac arteries and AL following esophagectomy. Some studies suggest celiac trunk stenosis as a more appropriate surrogate. Our up-to-date review highlights the need for automated quantification of aortic calcifications, as well as the degree of celiac trunk stenosis in preoperative computed tomography in patients undergoing esophagectomy, to obtain robust and reproducible measurements that can be used for a definite correlation.