Clopidogrel-induced Eosinophilia with Hypercalcemia

• Published in: Internal Medicine Vol. 61; no. 17; pp. 2681 - 2685
• Main Authors: Yamada, Kazuhiro, Asai, Kazuhisa, Yanagimoto, Misaki, Sone, Risa, Inazu, Satsuki, Mizutani, Ryo, Kadotani, Hideaki, Watanabe, Tetsuya, Tochino, Yoshihiro, Kawaguchi, Tomoya
• Format: Journal Article
• Language: English
• Published: Tokyo The Japanese Society of Internal Medicine 01.09.2022; Japan Science and Technology Agency
• Subjects: Asthma; Case Report; Clopidogrel; Computed tomography; drug-induced eosinophilia; Eosinophilia; Hypercalcemia; Internal medicine; Lung nodules; Lymphadenopathy
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.7830-21

There are few cases describing the association of eosinophilia with hypercalcemia, and drug-induced eosinophilia with hypercalcemia has not been reported. A 74-year-old man had been diagnosed with asthma 4 months earlier. He was admitted due to eosinophilia with hypercalcemia. Chest computed tomography showed a nodule in the left lung and mediastinal lymphadenopathy. By obtaining a detailed medical history, clopidogrel was suspected as the prime cause of eosinophilia. After the discontinuation of clopidogrel, the eosinophilia with hypercalcemia, lung nodule and mediastinal lymphadenopathy improved. Clopidogrel-induced eosinophilia can potentially cause hypercalcemia. Obtaining a detailed clinical history is important in diagnosing the cause of eosinophilia.