Anti-inflammatory Properties of the Alpha-Melanocyte-Stimulating Hormone in Models of Granulomatous Inflammation

• Published in: Lung Vol. 200; no. 4; pp. 463 - 472
• Main Authors: Shahraki, Abdolrazagh Hashemi, Tian, Runxia, Zhang, Chongxu, Fregien, Nevis L., Bejarano, Pablo, Mirsaeidi, Mehdi
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2022; Springer; Springer Nature B.V
• Subjects: a-Melanocyte-stimulating hormone; Animal models; Anti-inflammatory agents; Anti-inflammatory drugs; Biochips; Biological response modifiers; Chemical compounds; Cytokines; Cytotoxicity; Epithelial cells; Epithelium; Granulomas; In vitro methods and tests; Inflammation; Interferon; Intermedin; Lungs; Lymphocytes T; Macrophages; Medicine; Medicine & Public Health; Melanocyte-stimulating hormone; Pathogenesis; Pharmacology; Pneumology/Respiratory System; Sarcoidosis; T cells; Three dimensional models; In vitro granuloma model; Bronchial epithelial cells; Type I interferons; Sarcoidosis; α-MSH; Mice model

Purpose Alpha-melanocyte stimulating hormone (α-MSH) is known to have anti-inflammatory effects. However, the anti-inflammatory properties of α-MSH on normal bronchial epithelial cells are largely unknown, especially in the context of in vitro sarcoidosis models. Methods We evaluated the anti-inflam...