Anti-inflammatory Properties of the Alpha-Melanocyte-Stimulating Hormone in Models of Granulomatous Inflammation

Purpose Alpha-melanocyte stimulating hormone (α-MSH) is known to have anti-inflammatory effects. However, the anti-inflammatory properties of α-MSH on normal bronchial epithelial cells are largely unknown, especially in the context of in vitro sarcoidosis models. Methods We evaluated the anti-inflam...

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Published inLung Vol. 200; no. 4; pp. 463 - 472
Main Authors Shahraki, Abdolrazagh Hashemi, Tian, Runxia, Zhang, Chongxu, Fregien, Nevis L., Bejarano, Pablo, Mirsaeidi, Mehdi
Format Journal Article
LanguageEnglish
Published New York Springer US 01.08.2022
Springer
Springer Nature B.V
Subjects
a-Melanocyte-stimulating hormone
Animal models
Anti-inflammatory agents
Anti-inflammatory drugs
Biochips
Biological response modifiers
Chemical compounds
Cytokines
Cytotoxicity
Epithelial cells
Epithelium
Granulomas
In vitro methods and tests
Inflammation
Interferon
Intermedin
Lungs
Lymphocytes T
Macrophages
Medicine
Medicine & Public Health
Melanocyte-stimulating hormone
Pathogenesis
Pharmacology
Pneumology/Respiratory System
Sarcoidosis
T cells
Three dimensional models
In vitro granuloma model
Bronchial epithelial cells
Type I interferons
Sarcoidosis
α-MSH
Mice model
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Summary:Purpose Alpha-melanocyte stimulating hormone (α-MSH) is known to have anti-inflammatory effects. However, the anti-inflammatory properties of α-MSH on normal bronchial epithelial cells are largely unknown, especially in the context of in vitro sarcoidosis models. Methods We evaluated the anti-inflammatory effects of α-MSH on two different in vitro sarcoidosis models (lung-on-membrane model; LOMM and three-dimensional biochip pulmonary sarcoidosis model; 3D-BSGM) generated from NBECs and an in vivo sarcoidosis mouse model. Results Treatment with α-MSH decreased inflammatory cytokine levels and downregulated type I interferon pathway genes and related proteins in LOMM and 3D-BSGM models. Treatment with α-MSH also significantly decreased macrophages and cytotoxic T-cells counts in a sarcoidosis mice model. Conclusion Our results confirm the direct role of type I IFNs in the pathogenesis of sarcoid lung granulomas and highlight α-MSH as a potential novel therapeutic agent for treating pulmonary sarcoidosis. Graphical Abstract
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ISSN:0341-2040
1432-1750
DOI:10.1007/s00408-022-00546-x