Advanced Strategies for Production of Natural Products in Yeast

Natural products account for more than 50% of all small-molecule pharmaceutical agents currently in clinical use. However, low availability often becomes problematic when a bioactive natural product is promising to become a pharmaceutical or leading compound. Advances in synthetic biology and metabo...

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Published iniScience Vol. 23; no. 3; p. 100879
Main Authors Chen, Ruibing, Yang, Shan, Zhang, Lei, Zhou, Yongjin J.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 27.03.2020
Elsevier
Subjects
Bioengineering
Biological Sciences
Biotechnology
Metabolic Engineering
Microbial Biotechnology
Review
Bioengineering
Metabolic Engineering
Biological Sciences
Biotechnology
Microbial Biotechnology
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Abstract Natural products account for more than 50% of all small-molecule pharmaceutical agents currently in clinical use. However, low availability often becomes problematic when a bioactive natural product is promising to become a pharmaceutical or leading compound. Advances in synthetic biology and metabolic engineering provide a feasible solution for sustainable supply of these compounds. In this review, we have summarized current progress in engineering yeast cell factories for production of natural products, including terpenoids, alkaloids, and phenylpropanoids. We then discuss advanced strategies in metabolic engineering at three different dimensions, including point, line, and plane (corresponding to the individual enzymes and cofactors, metabolic pathways, and the global cellular network). In particular, we comprehensively discuss how to engineer cofactor biosynthesis for enhancing the biosynthesis efficiency, other than the enzyme activity. Finally, current challenges and perspective are also discussed for future engineering direction. [Display omitted] Biological Sciences; Bioengineering; Metabolic Engineering; Biotechnology; Microbial Biotechnology
AbstractList Natural products account for more than 50% of all small-molecule pharmaceutical agents currently in clinical use. However, low availability often becomes problematic when a bioactive natural product is promising to become a pharmaceutical or leading compound. Advances in synthetic biology and metabolic engineering provide a feasible solution for sustainable supply of these compounds. In this review, we have summarized current progress in engineering yeast cell factories for production of natural products, including terpenoids, alkaloids, and phenylpropanoids. We then discuss advanced strategies in metabolic engineering at three different dimensions, including point, line, and plane (corresponding to the individual enzymes and cofactors, metabolic pathways, and the global cellular network). In particular, we comprehensively discuss how to engineer cofactor biosynthesis for enhancing the biosynthesis efficiency, other than the enzyme activity. Finally, current challenges and perspective are also discussed for future engineering direction. Biological Sciences; Bioengineering; Metabolic Engineering; Biotechnology; Microbial Biotechnology
Natural products account for more than 50% of all small-molecule pharmaceutical agents currently in clinical use. However, low availability often becomes problematic when a bioactive natural product is promising to become a pharmaceutical or leading compound. Advances in synthetic biology and metabolic engineering provide a feasible solution for sustainable supply of these compounds. In this review, we have summarized current progress in engineering yeast cell factories for production of natural products, including terpenoids, alkaloids, and phenylpropanoids. We then discuss advanced strategies in metabolic engineering at three different dimensions, including point, line, and plane (corresponding to the individual enzymes and cofactors, metabolic pathways, and the global cellular network). In particular, we comprehensively discuss how to engineer cofactor biosynthesis for enhancing the biosynthesis efficiency, other than the enzyme activity. Finally, current challenges and perspective are also discussed for future engineering direction.Natural products account for more than 50% of all small-molecule pharmaceutical agents currently in clinical use. However, low availability often becomes problematic when a bioactive natural product is promising to become a pharmaceutical or leading compound. Advances in synthetic biology and metabolic engineering provide a feasible solution for sustainable supply of these compounds. In this review, we have summarized current progress in engineering yeast cell factories for production of natural products, including terpenoids, alkaloids, and phenylpropanoids. We then discuss advanced strategies in metabolic engineering at three different dimensions, including point, line, and plane (corresponding to the individual enzymes and cofactors, metabolic pathways, and the global cellular network). In particular, we comprehensively discuss how to engineer cofactor biosynthesis for enhancing the biosynthesis efficiency, other than the enzyme activity. Finally, current challenges and perspective are also discussed for future engineering direction.
Natural products account for more than 50% of all small-molecule pharmaceutical agents currently in clinical use. However, low availability often becomes problematic when a bioactive natural product is promising to become a pharmaceutical or leading compound. Advances in synthetic biology and metabolic engineering provide a feasible solution for sustainable supply of these compounds. In this review, we have summarized current progress in engineering yeast cell factories for production of natural products, including terpenoids, alkaloids, and phenylpropanoids. We then discuss advanced strategies in metabolic engineering at three different dimensions, including point, line, and plane (corresponding to the individual enzymes and cofactors, metabolic pathways, and the global cellular network). In particular, we comprehensively discuss how to engineer cofactor biosynthesis for enhancing the biosynthesis efficiency, other than the enzyme activity. Finally, current challenges and perspective are also discussed for future engineering direction. [Display omitted] Biological Sciences; Bioengineering; Metabolic Engineering; Biotechnology; Microbial Biotechnology
Natural products account for more than 50% of all small-molecule pharmaceutical agents currently in clinical use. However, low availability often becomes problematic when a bioactive natural product is promising to become a pharmaceutical or leading compound. Advances in synthetic biology and metabolic engineering provide a feasible solution for sustainable supply of these compounds. In this review, we have summarized current progress in engineering yeast cell factories for production of natural products, including terpenoids, alkaloids, and phenylpropanoids. We then discuss advanced strategies in metabolic engineering at three different dimensions, including point, line, and plane (corresponding to the individual enzymes and cofactors, metabolic pathways, and the global cellular network). In particular, we comprehensively discuss how to engineer cofactor biosynthesis for enhancing the biosynthesis efficiency, other than the enzyme activity. Finally, current challenges and perspective are also discussed for future engineering direction.
Natural products account for more than 50% of all small-molecule pharmaceutical agents currently in clinical use. However, low availability often becomes problematic when a bioactive natural product is promising to become a pharmaceutical or leading compound. Advances in synthetic biology and metabolic engineering provide a feasible solution for sustainable supply of these compounds. In this review, we have summarized current progress in engineering yeast cell factories for production of natural products, including terpenoids, alkaloids, and phenylpropanoids. We then discuss advanced strategies in metabolic engineering at three different dimensions, including point, line, and plane (corresponding to the individual enzymes and cofactors, metabolic pathways, and the global cellular network). In particular, we comprehensively discuss how to engineer cofactor biosynthesis for enhancing the biosynthesis efficiency, other than the enzyme activity. Finally, current challenges and perspective are also discussed for future engineering direction. : Biological Sciences; Bioengineering; Metabolic Engineering; Biotechnology; Microbial Biotechnology Subject Areas: Biological Sciences, Bioengineering, Metabolic Engineering, Biotechnology, Microbial Biotechnology
ArticleNumber 100879
Author Zhou, Yongjin J.
Zhang, Lei
Chen, Ruibing
Yang, Shan
AuthorAffiliation 6 University of Chinese Academy of Sciences, Beijing 100049, China
1 Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China
3 Department of Pharmaceutical Botany, School of Pharmacy, Naval Medical University, Shanghai 200433, China
2 CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
4 Biomedical Innovation R&D Center, School of Medicine, Shanghai University, Shanghai 200444, China
5 Dalian Key Laboratory of Energy Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China
AuthorAffiliation_xml – name: 2 CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
– name: 1 Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China
– name: 4 Biomedical Innovation R&D Center, School of Medicine, Shanghai University, Shanghai 200444, China
– name: 5 Dalian Key Laboratory of Energy Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China
– name: 3 Department of Pharmaceutical Botany, School of Pharmacy, Naval Medical University, Shanghai 200433, China
– name: 6 University of Chinese Academy of Sciences, Beijing 100049, China
Author_xml – sequence: 1
  givenname: Ruibing
  surname: Chen
  fullname: Chen, Ruibing
  organization: Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China
– sequence: 2
  givenname: Shan
  surname: Yang
  fullname: Yang, Shan
  organization: Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China
– sequence: 3
  givenname: Lei
  surname: Zhang
  fullname: Zhang, Lei
  organization: Department of Pharmaceutical Botany, School of Pharmacy, Naval Medical University, Shanghai 200433, China
– sequence: 4
  givenname: Yongjin J.
  orcidid: 0000-0002-2369-3079
  surname: Zhou
  fullname: Zhou, Yongjin J.
  email: zhouyongjin@dicp.ac.cn
  organization: Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32087574$$D View this record in MEDLINE/PubMed
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Snippet Natural products account for more than 50% of all small-molecule pharmaceutical agents currently in clinical use. However, low availability often becomes...
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SubjectTerms Bioengineering
Biological Sciences
Biotechnology
Metabolic Engineering
Microbial Biotechnology
Review
Title Advanced Strategies for Production of Natural Products in Yeast
URI https://dx.doi.org/10.1016/j.isci.2020.100879
https://www.ncbi.nlm.nih.gov/pubmed/32087574
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Volume 23
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