Allogeneic haematopoietic stem cell transplantation in patients with human immunodeficiency virus: the experiences of more than 25 years

• Published in: Clinical and experimental immunology Vol. 163; no. 3; pp. 284 - 295
• Main Authors: Hütter, G, Zaia, J.A
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.03.2011; Blackwell; Oxford University Press; Blackwell Science Inc
• Subjects: allogeneic stem cell transplantation; Analytical, structural and metabolic biochemistry; Biological and medical sciences; Bone marrow; Bone marrow transplantation; Data processing; Expectancy; Fundamental and applied biological sciences. Psychology; gene therapy; Hematologic Neoplasms - etiology; Hematologic Neoplasms - therapy; Hematopoietic Stem Cell Transplantation - adverse effects; Hematopoietic Stem Cell Transplantation - methods; Hematopoietic Stem Cell Transplantation - trends; HIV; HIV Infections - complications; HIV Infections - drug therapy; HIV Infections - mortality; HIV Infections - therapy; Human immunodeficiency virus; Human immunodeficiency virus 1; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infection; Infectious diseases; Malignancy; Medical sciences; Peripheral blood; Review; stem cell transplantation; Stem cells; Transplants & implants; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Human; Immunopathology; Stem cell; Retroviridae; Hematopoietic cell; Homograft; AIDS; Biochemistry; Immune deficiency; Lentivirus; Infection; Virus; Treatment; Allogeneic hematopoietic stem cell transplantation; allogeneic stem cell transplantation; HIV; Viral disease; Graft; Human immunodeficiency virus; Gene therapy
• ISSN: 0009-9104; 1365-2249
• DOI: 10.1111/j.1365-2249.2010.04312.x

For treatment of several malignancies, transplantation of allogeneic haematopoietic stem cells (HSCT) derived from bone marrow or peripheral blood has been used as a therapeutic procedure for decades. In the past, HSCT has been suggested as a treatment option for infection with the human immunodeficiency virus type 1 (HIV-1), but these attempts were mostly unsuccessful. Today, after the introduction of an active anti-retroviral therapy, the lifetime expectancy of HIV-infected patients has improved substantially, but nevertheless the incidence rate of malignancies in these patients has increased considerably. Therefore, it can be assumed that there will be a rising necessity for HIV-1-infected patients with malignancies for allogeneic HSCT. At the same time, there is increasing interest in treatment methods which might target the HIV-1 reservoir more effectively, and the question has been raised as to whether allogeneic HSCT could be linked to such strategies. In this paper the data of more than 25 years experience with allogeneic HSCT in patients with HIV-1 are reviewed and analysed.