复方乙酰水杨酸片中有效成分的DOSY技术分析
复方乙酰水杨酸片是临床常用的解热镇痛消炎药物,目前其有效成分的分析方法存在操作繁琐而分析速度慢等不足.该文利用二甲基硅油(PDMS)辅助的扩散排序(DOSY)技术以及扩散排序-同核相关(DOSY-COSY)联用技术,成功地对复方乙酰水杨酸片中三种有效成分的分子结构进行了快速定性分析,并且利用核磁共振氢谱(~1H NMR)技术进行了相对定量分析.该方法具有方便、快捷等特点,可作为借鉴和参考用于药物的质量评价....
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Published in | 波谱学杂志 Vol. 33; no. 3; pp. 415 - 421 |
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Main Author | |
Format | Journal Article |
Language | Chinese |
Published |
青岛科技大学化工学院,山东青岛,266042%中国科学院青岛生物能源与过程研究所,山东省合成生物学省级重点实验室,山东青岛 266101
2016
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Subjects | |
Online Access | Get full text |
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Summary: | 复方乙酰水杨酸片是临床常用的解热镇痛消炎药物,目前其有效成分的分析方法存在操作繁琐而分析速度慢等不足.该文利用二甲基硅油(PDMS)辅助的扩散排序(DOSY)技术以及扩散排序-同核相关(DOSY-COSY)联用技术,成功地对复方乙酰水杨酸片中三种有效成分的分子结构进行了快速定性分析,并且利用核磁共振氢谱(~1H NMR)技术进行了相对定量分析.该方法具有方便、快捷等特点,可作为借鉴和参考用于药物的质量评价. |
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Bibliography: | Compound acetylsalicylic acid tablet is a clinical drug having antipyretic,analgesic and anti-inflammatory effects. The present methods to analyze the activeingredients in this drug have many disadvantages. In this study, we usedpolydimethylsiloxane (PDMS)-assisted diffusion ordered NMR spectroscopy (DOSY),DOSY-correlated spectroscopy (COSY), and relative quantitative 1H NMR techniques toanalyze the three main active ingredients in this drug. The content ratios among the 3components could be obtained. It is argued that PDMS-assisted DOSY provides aconvenient and efficient method for pharmaceutical quality control of compoundacetylsalicylic acid tablets. WANG Li-min,QIU Ru-chen,HUANG Shao-hua(School of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China;Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and BioprocessTechnology, Chinese Academy of Sciences, Qingdao 266101, China) 42-1180/O4 acetylsalicylic acid, pharmaceutical quality cont |
ISSN: | 1000-4556 |
DOI: | 10.11938/cjmr20160306 |