多种肿瘤标志物在肺腺癌中的表达及预后意义的研究
背景与目的肺腺癌是最常见的肺癌组织学类型，发病率呈上升趋势。本研究旨在探讨NapsinA、TTF-1、ERCC1、RRM1、EGFR、HER2、ERa、ERB、PR、Bcl-2蛋白在肺腺癌中的表达及与临床病理特征和预后的关系。方法将227例肺腺癌石蜡标本构建组织芯片。采用免疫组化方法检测10种靶蛋白标记物在肺腺癌中的表达，分析各蛋白表达与患者临床病理特征和预后的关系。结果10种蛋白中仅NapsinA蛋白表达与性别有关（P=0．049）；Napsin A、PR和EGFR蛋白表达与吸烟有关，TTF-1和ERCC1蛋白表达与肿瘤大小有关，NapsinA、TTF-1、ERα和PR蛋白表达与肿瘤分化程度...
Saved in:
| Published in | 中国肺癌杂志 Vol. 17; no. 3; pp. 243 - 253 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
北京协和医学院中国医学科学院肿瘤医院病理科,北京,100021
2014
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1009-3419 1999-6187 |
| DOI | 10.3779/j.issn.1009-3419.2014.03.11 |
Cover
| Abstract | 背景与目的肺腺癌是最常见的肺癌组织学类型，发病率呈上升趋势。本研究旨在探讨NapsinA、TTF-1、ERCC1、RRM1、EGFR、HER2、ERa、ERB、PR、Bcl-2蛋白在肺腺癌中的表达及与临床病理特征和预后的关系。方法将227例肺腺癌石蜡标本构建组织芯片。采用免疫组化方法检测10种靶蛋白标记物在肺腺癌中的表达，分析各蛋白表达与患者临床病理特征和预后的关系。结果10种蛋白中仅NapsinA蛋白表达与性别有关（P=0．049）；Napsin A、PR和EGFR蛋白表达与吸烟有关，TTF-1和ERCC1蛋白表达与肿瘤大小有关，NapsinA、TTF-1、ERα和PR蛋白表达与肿瘤分化程度有关，TTF-1、Bcl-2和ERCC1蛋白表达与病理分期有关（P〈0．05）。10种蛋白表达均与年龄无关，ERβ、HER2和RRM1蛋白表达与各项临床病理参数均无相关性（P〉0．05）。单因素生存分析显示，NapsinA、TTF．1和ERCC1蛋白表达与患者总生存相关；TTF-1蛋白表达与患者无病生存相关（P〈0．05）。进一步分析I期肺腺癌，仅NapsinA蛋白表达与患者总生存相关，P〈0．05；10种蛋白表达均与I期患者无病生存无关（P〉0．05）。经多因素生存分析，仅病理分期与患者总生存和无病生存相关（P〈0．05）；10种蛋白表达均未显示与患者生存的相关（P〉0．05）。结论Napsin A、TrF-1和ERCC1蛋白可能是提示肺腺癌患者预后较好的标记物。 |
|---|---|
| AbstractList | 背景与目的肺腺癌是最常见的肺癌组织学类型，发病率呈上升趋势。本研究旨在探讨Napsin A、TTF-1、ERCC1、RRM1、EGFR、HER2、ERα、ERβ、PR、Bcl-2蛋白在肺腺癌中的表达及与临床病理特征和预后的关系。方法将227例肺腺癌石蜡标本构建组织芯片。采用免疫组化方法检测10种靶蛋白标记物在肺腺癌中的表达，分析各蛋白表达与患者临床病理特征和预后的关系。结果10种蛋白中仅Napsin A蛋白表达与性别有关（P=0.049）；Napsin A、PR和EGFR蛋白表达与吸烟有关，TTF-1和ERCC1蛋白表达与肿瘤大小有关，Napsin A、TTF-1、ERα和PR蛋白表达与肿瘤分化程度有关，TTF-1、Bcl-2和ERCC1蛋白表达与病理分期有关（P<0.05）。10种蛋白表达均与年龄无关，ERβ、HER2和RRM1蛋白表达与各项临床病理参数均无相关性（P>0.05）。单因素生存分析显示，Napsin A、TTF-1和ERCC1蛋白表达与患者总生存相关；TTF-1蛋白表达与患者无病生存相关（P<0.05）。进一步分析I期肺腺癌，仅Napsin A蛋白表达与患者总生存相关，P<0.05；10种蛋白表达均与I期患者无病生存无关（P>0.05）。经多因素生存分析，仅病理分期与患者总生存和无病生存相关（P<0.05）；10种蛋白表达均未显示与患者生存的相关（P>0.05）。结论 Napsin A、TTF-1和ERCC1蛋白可能是提示肺腺癌患者预后较好的标记物。 背景与目的肺腺癌是最常见的肺癌组织学类型，发病率呈上升趋势。本研究旨在探讨NapsinA、TTF-1、ERCC1、RRM1、EGFR、HER2、ERa、ERB、PR、Bcl-2蛋白在肺腺癌中的表达及与临床病理特征和预后的关系。方法将227例肺腺癌石蜡标本构建组织芯片。采用免疫组化方法检测10种靶蛋白标记物在肺腺癌中的表达，分析各蛋白表达与患者临床病理特征和预后的关系。结果10种蛋白中仅NapsinA蛋白表达与性别有关（P=0．049）；Napsin A、PR和EGFR蛋白表达与吸烟有关，TTF-1和ERCC1蛋白表达与肿瘤大小有关，NapsinA、TTF-1、ERα和PR蛋白表达与肿瘤分化程度有关，TTF-1、Bcl-2和ERCC1蛋白表达与病理分期有关（P〈0．05）。10种蛋白表达均与年龄无关，ERβ、HER2和RRM1蛋白表达与各项临床病理参数均无相关性（P〉0．05）。单因素生存分析显示，NapsinA、TTF．1和ERCC1蛋白表达与患者总生存相关；TTF-1蛋白表达与患者无病生存相关（P〈0．05）。进一步分析I期肺腺癌，仅NapsinA蛋白表达与患者总生存相关，P〈0．05；10种蛋白表达均与I期患者无病生存无关（P〉0．05）。经多因素生存分析，仅病理分期与患者总生存和无病生存相关（P〈0．05）；10种蛋白表达均未显示与患者生存的相关（P〉0．05）。结论Napsin A、TrF-1和ERCC1蛋白可能是提示肺腺癌患者预后较好的标记物。 |
| Abstract_FL | Background and objective Lung adenocarcinoma is one of the most common histological subtypes of lung cancer. hTe incidence of this disease was continuously increased. hTis study aims to detect the expressions of Napsin A, TTF-1, ERCC1, RRM1, EGFR, HER2, ERα, ERβ, PR, and Bcl-2 in lung adenocarcinoma and to explore their correlations with clinicopathological characteristics and prognosis. Methods A total of 227 lung adenocarcinoma specimens were constructed in tissue microarrays. The expressions of the 10 tumor biomarkers were analyzed by immunohistochemistry on paraffin-embedded sections. Results Among the 10 markers, Napsin A was gender-related (P=0.049). Napsin A, PR, and EGFR were signiifcantly associated with smoking. TTF-1 and ERCC1 were closely associated with tumor size. Napsin A, TTF-1, ERα, and PR were remarkably associated with tumor differentiation. TTF-1, Bcl-2, and ERCC1 were closely associated with tumor stage (P<0.05). No marker was related to age. No correlations were observed between ERβ, HER2, and RRM1 expressions and clini-copathological parameters (P>0.05). Univariate analysis results showed that Napsin A, TTF-1, and ERCC1 were signiifcantly associated with overall survival. TTF-1 was remarkably associated with disease-free survival (P<0.05). Stage I cases were further analyzed and revealed that only Napsin A expression was associated with overall survival (P<0.05). No marker was correlated with disease-free survival (P>0.05). Multivariate analysis results showed that pathological staging was signiifcantly associated with overall survival and disease-free survival (P<0.05). No marker was identiifed as a predictor of patient outcome (P>0.05). Conclusion Napsin A, TTF-1, and ERCC1 are the markers indicating good prognosis of lung adenocarcinoma. |
| Author | 杨欣 薛丽燕 郭蕾 温芃 林冬梅 |
| AuthorAffiliation | 北京协和医学院中国医学科学院肿瘤医院病理科,北京100021 |
| AuthorAffiliation_xml | – name: 北京协和医学院中国医学科学院肿瘤医院病理科,北京,100021 |
| Author_FL | Xin YANG Liyan XUE Lei GUO Peng WEN Dongmei LIN |
| Author_FL_xml | – sequence: 1 fullname: Xin YANG – sequence: 2 fullname: Liyan XUE – sequence: 3 fullname: Lei GUO – sequence: 4 fullname: Peng WEN – sequence: 5 fullname: Dongmei LIN |
| Author_xml | – sequence: 1 fullname: 杨欣 薛丽燕 郭蕾 温芃 林冬梅 |
| BookMark | eNo1z01LAkEYB_AhDFLrQ0SHTrvNszO7O3MMsRcQuniX2ZcxpcZyicijGGFUdggq6WAhpIeuUR70y7ju9i1asU7Pw8OP588_g1KqpnyENgDrxLb5VlWvBIHSAWOuEQpcNzBQHRMdYAmlgXOuWcDsVLL_kxWUCYIqxpbBCU2jfNjvRu-3cXMSPfVnvatw8hi1h-HLIG6O4stR9Hwz_fqIuq34dRCPx2Hn-uetFd7fzVqd6Xc7uUe9h2j4uYqWpTgK_LW_mUXFnXwxt6cVDnb3c9sFzTWZrQmfEI8BZ5hybDOHOhTA9UxuEoNJh2CLU8mY40jgjmOZvmFL5tGkhQumlIJk0ebi7blQUqhyqVo7q6sksNQoS9FozNtjgsFO5PpCuoc1VT6tJPakXjkW9YtSkm3B3P0C56x1EQ |
| ContentType | Journal Article |
| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| Copyright_xml | – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| DBID | 2RA 92L CQIGP W91 ~WA 2B. 4A8 92I 93N PSX TCJ |
| DOI | 10.3779/j.issn.1009-3419.2014.03.11 |
| DatabaseName | 中文科技期刊数据库 中文科技期刊数据库-CALIS站点 中文科技期刊数据库-7.0平台 中文科技期刊数据库-医药卫生 中文科技期刊数据库- 镜像站点 Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitleAlternate | Clinicopathological and Prognostic Significance of a Panel of Tumor Biomarkers in Lung Adenocarcinoma： a Tissue Microarray Study |
| DocumentTitle_FL | Clinicopathological and Prognostic Signiifcance of a Panel of Tumor Biomarkers in Lung Adenocarcinoma:a Tissue Microarray Study |
| EISSN | 1999-6187 |
| EndPage | 253 |
| ExternalDocumentID | zgfazz201403017 49061140 |
| GroupedDBID | --- -05 04C 29R 2B. 2C~ 2RA 2WC 3V. 5GY 5VS 6PF 92F 92I 92L AAWTL ABUWG ACGFS AFKRA ALMA_UNASSIGNED_HOLDINGS BENPR BPHCQ BVBZV C1A CCEZO CCPQU CIEJG CQIGP CW9 DIK E3Z EBD EIHBH EMOBN EOJEC F5P GROUPED_DOAJ HYE IPNFZ KQ8 KWQ OBODZ OK1 PIMPY PQQKQ PROAC RIG RNS RPM TCJ TGQ U1G U5O W91 ~WA 4A8 93N PGMZT PHGZM PHGZT PMFND PSX |
| ID | FETCH-LOGICAL-c587-ae33d8198049078b4b411cd595328fb30694f88bbf19bb65e27f8d4999c15ffa3 |
| ISSN | 1009-3419 |
| IngestDate | Thu May 29 03:56:17 EDT 2025 Wed Feb 14 10:38:02 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | Immunohistochemistry Prognosis 组织芯片 预后 Tissue microarray 肺肿瘤 免疫组化 Lung neoplasms |
| Language | Chinese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c587-ae33d8198049078b4b411cd595328fb30694f88bbf19bb65e27f8d4999c15ffa3 |
| Notes | Tissue microarray; Immunohistochemistry; Lung neoplasms; Prognosis Xin YANG, Liyan XUE, Lei GUO, Peng WEN, （Dongmei LIN Department of Pathology, Cancer Institute （Hospital）, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021j China） 12-1395/R Background and objective Lung adenocarcinoma is one of the most common histological subtypes of lung cancer. The incidence of this disease was continuously increased. This study aims to detect the expressions of Napsin A, TTF- 1, ERCC1, RRM1, EGFR, HER2, ERa, ERβ, PR, and Bcl-2 in lung adenocarcinoma and to explore their correlations with clinicopathological characteristics and prognosis. Methods A total of 227 lung adenocarcinoma specimens were constructed in tissue microarrays. The expressions of the 10 tumor biomarkers were analyzed by immunohistochemistry on paraffinembedded sections. Results Among the 10 markers, Napsin A was gender-related （P=0.049）. Napsin A, PR, and EGFR were significantly associated with smoking. TTF-1 and ERCC1 were |
| PageCount | 11 |
| ParticipantIDs | wanfang_journals_zgfazz201403017 chongqing_primary_49061140 |
| PublicationCentury | 2000 |
| PublicationDate | 2014 |
| PublicationDateYYYYMMDD | 2014-01-01 |
| PublicationDate_xml | – year: 2014 text: 2014 |
| PublicationDecade | 2010 |
| PublicationTitle | 中国肺癌杂志 |
| PublicationTitleAlternate | Chinese Journal of Lung Cancer |
| PublicationTitle_FL | Chinese Journal of Lung Cancer |
| PublicationYear | 2014 |
| Publisher | 北京协和医学院中国医学科学院肿瘤医院病理科,北京,100021 |
| Publisher_xml | – name: 北京协和医学院中国医学科学院肿瘤医院病理科,北京,100021 |
| SSID | ssj0062934 ssib002262905 ssib044765436 ssib001103766 ssib038074678 ssib051369142 |
| Score | 1.9715668 |
| Snippet | ... 背景与目的肺腺癌是最常见的肺癌组织学类型，发病率呈上升趋势。本研究旨在探讨Napsin... |
| SourceID | wanfang chongqing |
| SourceType | Aggregation Database Publisher |
| StartPage | 243 |
| SubjectTerms | 免疫组化 组织芯片 肺肿瘤 预后 |
| Title | 多种肿瘤标志物在肺腺癌中的表达及预后意义的研究 |
| URI | http://lib.cqvip.com/qk/91098A/201403/49061140.html https://d.wanfangdata.com.cn/periodical/zgfazz201403017 |
| Volume | 17 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnR3LbtQw0OpDqrggnqIFqkrg45aNnTj2MdlNVSG1QqhIva3i7KY9bXlsL3usilARUA5IQMWhoEq0B64Iemj_gi_oNstfMONks6Fd8ai0irzj8Tw8SWbs2GNCbodxXds8tkvlUHAYoDSikqrzqBSD86_rCDyuOT9lbl7MPrDvLjqLQ8M_CquWVlt6OmoP3FdyFqsCDOyKu2T_w7I5UQBAGewLV7AwXP_JxjRwqGdT5dHApZ5LZZUGkkpG_RmEKIm1gaBemcKYH5ABrlyskop6CiGqQj3Za-WZgmMK0FxRWaGBTX2gUzUQj0obcTwra-UH-AM6coZKaAVkmcEBysA0QO7wF2qRjkK-fTouCqbSgqK-KAbKBb5Ayqd-tSBkLpugqorAnmq92yerQRlBe1CR92skVQIppgx8oxj0TnoIZ4oCxLlhDbhAOSiSRaGUkQWU4MVJE6s_XWp6pGL62kaJQQSEVE1HgD7MSG9wfN9YEYQVyFiZHhyg_GlkY3JlDWp--ibIm-c4LooHxsYCmKpAkFUGyM8q-I0m3WeeeTH84oWJ-goPMC96qTQzVhbwsDRb80lfipkojS9FktM5SVwNaWNe4MxH_p6svL0Uh-02ouBQ2x0mo8x1LWeEjPrB_L37_UAdt6cWJw6YYKrvefAUBPDguWewbRf3QOf4jsWFsuw8URw0TteP9KQcI7cyFe78QQHMp7K80lx6BFGi2bTXjMPmUiG-XLhAzmcDwykvfcovkqH28iUyNpctfblMgs7OVvL5ZXftMHm3c7z9rHP4NtnY63zY7a7td5_uJ-9fHH37kmytdz_udg8OOpvPf35a77x-dby-efR9A-DJ9ptk7-sVsjATLFRmS9kZKKXIAfcfNjivQ9Au8QO9K7WtbcuK6o5yOJOx5rhtPZZS69hSWgunwdxY1nEWI7KcOA75VTLSXGk2rpEpGOcxpctMcB1CydEOxKZCK9YoR2HoRONkIu-M2sM01U0NuAoLjDlOprLeqWXvvye1E7ae-DvKdXIOy-kM5g0y0nq82rgJMX1LT2Y3yKSZE_sFBy-6cw |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E5%A4%9A%E7%A7%8D%E8%82%BF%E7%98%A4%E6%A0%87%E5%BF%97%E7%89%A9%E5%9C%A8%E8%82%BA%E8%85%BA%E7%99%8C%E4%B8%AD%E7%9A%84%E8%A1%A8%E8%BE%BE%E5%8F%8A%E9%A2%84%E5%90%8E%E6%84%8F%E4%B9%89%E7%9A%84%E7%A0%94%E7%A9%B6&rft.jtitle=%E4%B8%AD%E5%9B%BD%E8%82%BA%E7%99%8C%E6%9D%82%E5%BF%97&rft.au=%E6%9D%A8%E6%AC%A3&rft.au=%E8%96%9B%E4%B8%BD%E7%87%95&rft.au=%E9%83%AD%E8%95%BE&rft.au=%E6%B8%A9%E8%8A%83&rft.date=2014&rft.pub=%E5%8C%97%E4%BA%AC%E5%8D%8F%E5%92%8C%E5%8C%BB%E5%AD%A6%E9%99%A2%E4%B8%AD%E5%9B%BD%E5%8C%BB%E5%AD%A6%E7%A7%91%E5%AD%A6%E9%99%A2%E8%82%BF%E7%98%A4%E5%8C%BB%E9%99%A2%E7%97%85%E7%90%86%E7%A7%91%2C%E5%8C%97%E4%BA%AC%2C100021&rft.issn=1009-3419&rft.issue=3&rft.spage=243&rft.epage=253&rft_id=info:doi/10.3779%2Fj.issn.1009-3419.2014.03.11&rft.externalDocID=zgfazz201403017 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fimage.cqvip.com%2Fvip1000%2Fqk%2F91098A%2F91098A.jpg http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fzgfazz%2Fzgfazz.jpg |