HLA associations and HLA sharing in recurrent miscarriage: A systematic review and meta-analysis

• Published in: Human immunology Vol. 76; no. 5; pp. 362 - 373
• Main Authors: Meuleman, Tess, Lashley, Lisa E.L.O, Dekkers, Olaf M, van Lith, Jan M.M, Claas, Frans H.J, Bloemenkamp, Kitty W.M
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2015
• Subjects: Abortion, Habitual - genetics; Abortion, Habitual - immunology; Alleles; Allergy and Immunology; Female; Genetic Association Studies; Histocompatibility; Histocompatibility Antigens Class I - genetics; HLA alleles; HLA sharing; HLA-B Antigens - genetics; HLA-DRB1 Chains - genetics; HLA-E Antigens; Humans; Meta-analysis; Pregnancy; Recurrent miscarriage; Risk; Selection Bias; Systematic review; CDC; APS; sequence specific priming; Systematic review; complement dependent cytotoxicity; odds ratio; SLE; sequence specific oligonucleotides; recurrent miscarriage; restriction fragment length polymorphism; sequence based typing; systemic lupus erythematosus; two color fluorescence; HLA alleles; RFLP; OR; SBT; CI; rheumatoid arthritis; SSO; RA; HLA sharing; Meta-analysis; SSP; TCF; anti-phospholipid syndrome; confidence interval; RM; Recurrent miscarriage

Abstract Problem The aim of this meta-analysis was to evaluate whether specific maternal HLA alleles and HLA sharing of couples are associated with the occurrence of recurrent miscarriage (RM). Method of study A systematic literature search was performed for studies that evaluated the association be...