IgE, mast cells, basophils, and eosinophils

• Published in: Journal of allergy and clinical immunology Vol. 125; no. 2; pp. S73 - S80
• Main Authors: Stone, Kelly D., MD, PhD, Prussin, Calman, MD, Metcalfe, Dean D., MD
• Format: Journal Article
• Language: English
• Published: United States Mosby, Inc 01.02.2010; Elsevier Limited
• Subjects: Allergies; allergy; Allergy and Immunology; Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal - therapeutic use; Antibodies, Monoclonal, Humanized; basophils; Basophils - immunology; Basophils - metabolism; Basophils - pathology; Biomarkers - metabolism; Cell Degranulation; Cell Differentiation; Cell Movement; Chondroitin sulfate; Cytokines - secretion; Deoxyribonucleic acid; DNA; DNA repair; Eosinophils - immunology; Eosinophils - metabolism; Eosinophils - pathology; Food allergies; Humans; hypereosinophilic syndromes; Hypersensitivity, Immediate - blood; Hypersensitivity, Immediate - diagnosis; Hypersensitivity, Immediate - immunology; Hypersensitivity, Immediate - therapy; IgE; Immune system; Immunoglobulin E - immunology; Immunoglobulin E - metabolism; Kinases; Lymphocytes; mast cells; Mast Cells - immunology; Mast Cells - metabolism; Mast Cells - pathology; mastocytosis; Omalizumab; Receptors, IgE - immunology; Tryptases - blood; hypereosinophilic syndromes; CD40L; Eosinophil peroxidase; Activation induced deaminase; Major basic protein; Cysteinyl leukotriene; EPO; Platelet-activating factor; IgE; LT; basophils; mast cells; CysLT; EDN; Stem cell factor; Systemic mastocytosis; Signal transducer and activator of transcription 6; MBP; SM; STAT6; TLR; AID; Toll-like receptor; Prostaglandin; Eosinophil-derived neurotoxin; allergy; CEL; Leukotriene; Chronic eosinophilic leukemia; ECP; PAF; mastocytosis; ITAM; CD40 ligand; PG; SCF; Eosinophil cationic protein; Immunoreceptor tyrosine–based activation motif
• ISSN: 0091-6749; 1097-6825
• DOI: 10.1016/j.jaci.2009.11.017

IgE, mast cells, basophils, and eosinophils are essential components of allergic inflammation. Antigen-specific IgE production, with subsequent fixation of IgE to FcϵRI receptors on mast cells and basophils, is central to the initiation and propagation of immediate hypersensitivity reactions. Mast cells, basophils, and eosinophils are central effector cells in allergic inflammation, as well as in innate and adaptive immunity. This review highlights what is known about these components and their roles in disease pathogenesis.