Premature Red Blood Cells Have Decreased Aggregation and Enhanced Aggregability

Preterm infants are highly susceptible to ischemic damage. This damage is most obvious in the brain, retina, and gastrointestinal tract. Studies focusing on the rheological properties of premature red blood cells (pRBCs) have consistently shown minimal or no RBC aggregation. Previously, measurements...

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Bibliographic Details
Published inThe Journal of Physiological Sciences Vol. 58; no. 3; pp. 161 - 165
Main Authors Arbell, D., Orkin, B., Bar-Oz, B., Barshtein, G., Yedgar, S.
Format Journal Article
LanguageEnglish
Published Japan PHYSIOLOGICAL SOCIETY OF JAPAN 01.06.2008
BioMed Central
Subjects
Adult
aggregability
Dextrans - pharmacology
Erythrocyte Aggregation - physiology
Erythrocytes - cytology
Erythrocytes - drug effects
Humans
Infant, Newborn
Infant, Premature
Plasma - cytology
plasma factor
Plasma Substitutes - pharmacology
preterm infants
red blood cell aggregation
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Summary:Preterm infants are highly susceptible to ischemic damage. This damage is most obvious in the brain, retina, and gastrointestinal tract. Studies focusing on the rheological properties of premature red blood cells (pRBCs) have consistently shown minimal or no RBC aggregation. Previously, measurements of pRBC aggregation kinetics indicated that specific plasma properties are responsible for the decreased RBC aggregation observed in the neonates, but that their specific RBC properties do not affect it. However, the strength of interaction in the pRBC aggregates as a function of medium composition has not been tested. In our previous research, we described clinically relevant parameters, that is, the aggregate resistance to disaggregation by flow. With the help of a cell flow property analyzer (CFA), we can monitor RBC aggregation by direct visualization of its dynamics during flow. We used the CFA to examine pRBC (from 9 premature babies) in the natural plasma and in PBS buffer supplemented with dextran (500 kDa) to distinguish between RBC intrinsic-cellular and plasma factors. pRBCs suspended in the native plasma showed minimal or no aggregation in comparison to normal adult RBC. When we transferred pRBCs from the same sample to the dextran solution, enhanced resistance to disaggregation by flow was apparent.
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ISSN:1880-6546
1880-6562
DOI:10.2170/physiolsci.RP004408