Expansion of the dentate mossy fiber–CA3 projection in the brain-derived neurotrophic factor-enriched mouse hippocampus

• Published in: Neuroscience Vol. 288; pp. 10 - 23
• Main Authors: Isgor, C, Pare, C, McDole, B, Coombs, P, Guthrie, K
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 12.03.2015
• Subjects: Animals; brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - genetics; Brain-Derived Neurotrophic Factor - metabolism; CA3 Region, Hippocampal - cytology; CA3 Region, Hippocampal - growth & development; CA3 Region, Hippocampal - metabolism; Cell Count; dentate granule cells; Dentate Gyrus - growth & development; Dentate Gyrus - metabolism; epilepsy; Female; hippocampus; Male; Mice, Inbred C57BL; Mice, Transgenic; Neurology; Neurons - cytology; Neurons - metabolism; Pilocarpine; Rats; RNA, Messenger - metabolism; seizure; Seizures - metabolism; TrkB; epilepsy; tropomyosin-related kinase B receptor; DG; seizure; intra/infrapyramidal; inner molecular layer; molecular layer; phosphate buffer; Tris-buffered saline; transgenic CAMKIIa-BDNF mouse strain; MF; proBDNF; brain-derived neurotrophic factor; mossy fiber; SP; suprapyramidal; WT; dentate granule cells; ML; TBS; hippocampus; BDNF; granule cell layer; IML; TgBDNF; GCL; IIP; dentate gyrus; PB; TrkB; mature BDNF; prepro-brain-derived neurotrophic factor; mBDNF; wild-type
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2014.12.036

Highlights • BDNF expression is chronically increased in the hippocampus of TgBDNF mice. • Mossy fiber volume in CA3 is enlarged by 2–3 months of age in TgBDNF mice. • At seizure-prone ages (6–7 months) mossy fiber volume increases further. • By 8 months, granule cell number is also significantly increased in TgBDNF mice.