Regulation of oxidative stress in response to acute aerobic and resistance exercise in HIV-infected subjects: a case-control study

• Published in: AIDS care Vol. 22; no. 11; pp. 1410 - 1417
• Main Authors: Deresz, L.F., Sprinz, E., Kramer, A.S., Cunha, G., de Oliveira, A.R., Sporleder, H., de Freitas, D.R.J., Lazzarotto, A.R., Dall'Ago, P.
• Format: Journal Article
• Language: English
• Published: Abingdon Taylor & Francis Group 01.11.2010; Taylor & Francis; Taylor & Francis Ltd
• Subjects: Acquired immune deficiency syndrome; Adult; Aerobic exercise; AIDS; Antioxidants; Antioxidants - metabolism; Biological and medical sciences; Blood; Blood tests; Case-Control Studies; catalase; Catalase - blood; Enzymatic activity; Erythrocytes; Erythrocytes - metabolism; Exercise; Exercise - physiology; Exercise Test; Female; Fundamental and applied biological sciences. Psychology; Glutathione - blood; glutathione S-transferase; Glutathione Transferase - blood; HIV; HIV Infections - blood; HIV Infections - enzymology; HIV Infections - immunology; Human immunodeficiency virus; Human viral diseases; Humans; Illness and personality; Immune response; Immunology; Infectious diseases; Lipid Peroxidation - physiology; Male; Medical sciences; Middle Aged; Oxidative stress; Oxidative Stress - physiology; Personality, behavior and health; Physical activity; physical exercise; Plasma; Proteins; Psychology and medicine; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Public health; Resistance; thiobarbituric acid reactive substances; Thiobarbituric Acid Reactive Substances - metabolism; total glutathione; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; South America; Brazil; America; Social environment; Physical exercise; Human; Immunopathology; Oxidative stress; total glutathione; Enzyme; Transferases; Acute; thiobarbituric acid reactive substances; AIDS; Aerobe; Case control study; Experimental study; Immune deficiency; Infection; Peroxidases; Catalase; Glutathione transferase; Viral disease; glutathione S-transferase; Oxidoreductases; Public health; Glutathione
• ISSN: 0954-0121; 1360-0451; 1360-0451
• DOI: 10.1080/09540121003758549

Human immunodeficiency virus (HIV)-infected subjects have increased levels of oxidative stress which could impair immunological function and therefore contribute to the progression of AIDS. These characteristics are usually evaluated at rest and responses to exercise have yet to be evaluated. The aim of the present study was to assess the effect of a bout of aerobic exercise followed by resistance exercises on antioxidant system in HIV-infected and non-HIV subjects. There were included 14 cases (HIV-positive) and 14 controls (HIV-negative). The exercise protocol consisted of a single session of 20 minutes on a cycloergometer followed by a set of six resistance exercises. The activity of glutathione S-transferase (GST) and catalase were measured in plasma samples, total glutathione (TGSH) and thiobarbituric acid reactive substances (TBARS) were measured in erythrocytes. T CD4+ cells, T CD8+, viral load, complete blood count, and white blood count were also assessed. All measurements were performed at three times: baseline, after aerobic exercise, and after resistance exercises. At baseline, the HIV group had lower GST activity than controls, but after the exercise session GST values were similar in both groups. Compared to the control group TGSH was significantly lower in the HIV group at baseline, after aerobic and resistance exercises. The control group presented higher TBARS values after aerobic exercise compared to the HIV group. The neutrophil count was lower in the HIV group after aerobic and resistance exercises. These data indicate that HIV-infected subjects had lower antioxidant activity at rest. Physical exercise stimulated the enzymatic activity similarly in both groups.