A NEW ANTHRACYCLINE ANTIBIOTIC SN-706

• Published in: Journal of antibiotics Vol. 41; no. 12; pp. 1918 - 1921
• Main Authors: KIMURA, KEN-ICHI, KOYAMA, TADAYOSHI, NAKAYAMA, SHOJI, TAMURA, Komi, MIYATA, NOBUO, KAWANISHI, GOSEI
• Format: Journal Article
• Language: English
• Published: Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1988; Japan Antibiotics Research Association
• Subjects: Actinomadura roseoviolacea; Actinomadura roseoviolacea miuraensis; Animals; anthracycline antibiotics; antibiotic SN-706; Antibiotics, Antineoplastic - isolation & purification; Antibiotics, Antineoplastic - pharmacology; Antiviral drugs; Biological and medical sciences; Biotechnology; carminomycin; Carubicin - analogs & derivatives; Carubicin - isolation & purification; Carubicin - pharmacology; Chemical Phenomena; Chemistry; Daunorubicin - analogs & derivatives; Fundamental and applied biological sciences. Psychology; General pharmacology; Health. Pharmaceutical industry; Industrial applications and implications. Economical aspects; Medical sciences; Mice; Nocardia - metabolism; Pharmacology. Drug treatments; Physicochemical properties. Structure-activity relationships; Production of active biomolecules; Antineoplastic agent; Antibiotic; Molecular structure; Production; Bacteria; Isolation; Anthracyclins; Fermentation; Physicochemical properties
• ISSN: 0021-8820; 1881-1469
• DOI: 10.7164/antibiotics.41.1918

In addition to the macromolecular antibiotic SN-07, Actinomadura roseoviolacea var. miuraensis nov. var. (strain 07) produced many anthracycline antibiotics such as carminomycins and SN-07 chromophore. Here the authors report on the isolation, physico-chemical, biological properties and structure determination of one of these antibiotics, designated SN-706, and identified as a carminomycin analog with a different acetal moiety.