Hippocampus ghrelin signaling mediates appetite through lateral hypothalamic orexin pathways

Feeding behavior rarely occurs in direct response to metabolic deficit, yet the overwhelming majority of research on the biology of food intake control has focused on basic metabolic and homeostatic neurobiological substrates. Most animals, including humans, have habitual feeding patterns in which m...

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Bibliographic Details
Published ineLife Vol. 4
Main Authors Hsu, Ted M, Hahn, Joel D, Konanur, Vaibhav R, Noble, Emily E, Suarez, Andrea N, Thai, Jessica, Nakamoto, Emily M, Kanoski, Scott E
Format Journal Article
LanguageEnglish
Published England eLife Science Publications, Ltd 15.12.2015
eLife Sciences Publications, Ltd
eLife Sciences Publications Ltd
Subjects
Animals
Appetite
Cellular signal transduction
feeding
Ghrelin
Ghrelin - metabolism
GHSR
Hippocampus (Brain)
Hippocampus - physiology
Hypothalamus - physiology
learning
Male
Neural Pathways - physiology
Neurological research
Neuropeptides
Neuroscience
obesity
Orexins - metabolism
Physiological aspects
Rats, Sprague-Dawley
Signal Transduction
ventral hippocampus
GHSR
rat
ventral hippocampus
neuroscience
feeding
appetite
learning
obesity
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Summary:Feeding behavior rarely occurs in direct response to metabolic deficit, yet the overwhelming majority of research on the biology of food intake control has focused on basic metabolic and homeostatic neurobiological substrates. Most animals, including humans, have habitual feeding patterns in which meals are consumed based on learned and/or environmental factors. Here we illuminate a novel neural system regulating higher-order aspects of feeding through which the gut-derived hormone ghrelin communicates with ventral hippocampus (vHP) neurons to stimulate meal-entrained conditioned appetite. Additional results show that the lateral hypothalamus (LHA) is a critical downstream substrate for vHP ghrelin-mediated hyperphagia and that vHP ghrelin activated neurons communicate directly with neurons in the LHA that express the neuropeptide, orexin. Furthermore, activation of downstream orexin-1 receptors is required for vHP ghrelin-mediated hyperphagia. These findings reveal novel neurobiological circuitry regulating appetite through which ghrelin signaling in hippocampal neurons engages LHA orexin signaling.
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ISSN:2050-084X
2050-084X
DOI:10.7554/elife.11190