检测肺癌患者血清Cathepsin X及Cystatin C的临床意义

背景与目的组织蛋白酶X（Cathepsin X,Cat X）是最近发现的一种组织蛋白酶（Cathepsins,Cats）家族成员。近年来研究表明CatX与多种恶性肿瘤发生、发展有关。本研究旨在探讨肺癌患者血清CatX及cystatinC的表达与临床特征及预后的关系。方法采用ELISA法定量检测84例肺癌患者及36例健康对照者血清CatX及cystatinC表达。结果肺癌患者血清Cat X和cystatin C水平明显高于健康人（P〈0.01）;CatX水平与肺癌病理类型之间有相关的趋势（P=0.076）。血清cystatin C水平与肺癌TNM分期正相关（P=0.01）,cystatinC/C...

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Published in中国肺癌杂志 Vol. 16; no. 8; pp. 411 - 416
Main Author 张学德 侯彦丽 牛泽群 李维 孟夏 张娜 杨拴盈
Format Journal Article
LanguageChinese
Published 西安交通大学第二附属医院呼吸科,西安,710004 2013
Subjects
C
Cathepsin
Cystatin
X
肺肿瘤
血清
肺肿瘤
血清
Cathepsin X
Sera
Cystatin C
Lung neoplasms
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Summary:背景与目的组织蛋白酶X（Cathepsin X,Cat X）是最近发现的一种组织蛋白酶（Cathepsins,Cats）家族成员。近年来研究表明CatX与多种恶性肿瘤发生、发展有关。本研究旨在探讨肺癌患者血清CatX及cystatinC的表达与临床特征及预后的关系。方法采用ELISA法定量检测84例肺癌患者及36例健康对照者血清CatX及cystatinC表达。结果肺癌患者血清Cat X和cystatin C水平明显高于健康人（P〈0.01）;CatX水平与肺癌病理类型之间有相关的趋势（P=0.076）。血清cystatin C水平与肺癌TNM分期正相关（P=0.01）,cystatinC/CatX与淋巴结转移之间有相关趋势（P=0.058）。CatX表达水平与肺癌患者总生存期（overallsurvival,OS）相关,高水平CatX肺癌患者OS更短。Cox单因素回归示CatX高表达以及TNM分期是影响肺癌预后独立因素,Cox多因素回归显示,仅TNM分期是患者预后的独立危险因素。结论肺癌患者中血清CatX和cystatinC水平升高,检测肺癌患者Cat X和cystatin C血清水平对于指导临床肺癌诊断、评估预后有重要意义。
Bibliography:Cathepsin X; Cystatin C; Lung neoplasms; Sera
Background and objective Cathepsin X （Cat X） has been identified as a member of cathepsin family. Studies have shown that Cat X is involved in tumorigenesis and tumor development of various cancers. ＂Ihe aim of this study is to investigate the relationship between the clinicopathological prognosis and the levels of Cat X and cystatin C in the serum of patients with lung cancer. Methods Blood samples were collected from 84 patients with lung cancer and 36 healthy control subjects. Cat X and cystatin C were determined by quantitative ELISA. Results Cat X and cystatin C levels were significantly higher in the patients with lung cancer than that in the healthy control subjects （P〈0.01）. Cat X level was correlated with the pathological types of lung cancer （P=0.076）. Cystatin C was positively correlated with TNM stage （P=0.01）. Furthermore, cystatin C/Cat X was correlated with lymph node metastasis （P=0.058）. The patients with high Cat X levels experienced sig- nificant
ISSN:1009-3419
1999-6187
DOI:10.3779/j.issn.1009-3419.2013.08.04