Immunology of COVID-19: Current State of the Science

• Published in: Immunity (Cambridge, Mass.) Vol. 52; no. 6; pp. 910 - 941
• Main Authors: Vabret, Nicolas, Britton, Graham J., Gruber, Conor, Hegde, Samarth, Kim, Joel, Kuksin, Maria, Levantovsky, Rachel, Malle, Louise, Moreira, Alvaro, Park, Matthew D., Pia, Luisanna, Risson, Emma, Saffern, Miriam, Salomé, Bérengère, Esai Selvan, Myvizhi, Spindler, Matthew P., Tan, Jessica, van der Heide, Verena, Gregory, Jill K., Alexandropoulos, Konstantina, Bhardwaj, Nina, Brown, Brian D., Greenbaum, Benjamin, Gümüş, Zeynep H., Homann, Dirk, Horowitz, Amir, Kamphorst, Alice O., Curotto de Lafaille, Maria A., Mehandru, Saurabh, Merad, Miriam, Samstein, Robert M., Agrawal, Manasi, Aleynick, Mark, Belabed, Meriem, Brown, Matthew, Casanova-Acebes, Maria, Catalan, Jovani, Centa, Monica, Charap, Andrew, Chan, Andrew, Chen, Steven T., Chung, Jonathan, Bozkus, Cansu Cimen, Cody, Evan, Cossarini, Francesca, Dalla, Erica, Fernandez, Nicolas, Grout, John, Ruan, Dan Fu, Hamon, Pauline, Humblin, Etienne, Jha, Divya, Kodysh, Julia, Leader, Andrew, Lin, Matthew, Lindblad, Katherine, Lozano-Ojalvo, Daniel, Lubitz, Gabrielle, Magen, Assaf, Mahmood, Zafar, Martinez-Delgado, Gustavo, Mateus-Tique, Jaime, Meritt, Elliot, Moon, Chang, Noel, Justine, O’Donnell, Tim, Ota, Miyo, Plitt, Tamar, Pothula, Venu, Redes, Jamie, Reyes Torres, Ivan, Roberto, Mark, Sanchez-Paulete, Alfonso R., Shang, Joan, Schanoski, Alessandra Soares, Suprun, Maria, Tran, Michelle, Vaninov, Natalie, Wilk, C. Matthias, Aguirre-Ghiso, Julio, Bogunovic, Dusan, Cho, Judy, Faith, Jeremiah, Grasset, Emilie, Heeger, Peter, Kenigsberg, Ephraim, Krammer, Florian, Laserson, Uri
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 16.06.2020; Elsevier Limited
• Subjects: Adaptive immunity; Animals; Betacoronavirus - physiology; Clinical trials; Coronaviridae; Coronavirus Infections - diagnosis; Coronavirus Infections - immunology; Coronavirus Infections - pathology; Coronavirus Infections - therapy; Coronaviruses; COVID-19; Cytokines; Disease Susceptibility; Disease transmission; Epidemics; Humans; Immune response; Immunity, Innate; Immunologic Memory; Immunology; Infections; Inflammation - immunology; Inflammation - virology; Lymphocytes - immunology; Middle East respiratory syndrome; Myeloid Cells - immunology; Pandemics; Pathophysiology; Phosphorylation; Pneumonia, Viral - diagnosis; Pneumonia, Viral - immunology; Pneumonia, Viral - pathology; Pneumonia, Viral - therapy; Proteins; Respiratory diseases; Review; SARS-CoV-2; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Signal transduction; Tumor necrosis factor-TNF; Viral diseases; Viral infections; Viruses; Zoonoses; China

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an unprecedented effort from the scientific community to understand the biological underpinning of COVID19 pathophysiology. In...