Significance of Earlier Initiation of Chemotherapy for Lung Cancer Complicated with Primary or Secondary Nephrotic Syndrome following Its Appropriate Differential Diagnosis

We encountered a case of primary lung cancer complicated with membranous nephropathy as primary nephrotic syndrome. Because treatment approaches vary greatly for primary and secondary nephrotic syndrome, a renal biopsy was performed for diagnosis. Much time was required to make a definitive diagnosi...

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Published inCase reports in oncology Vol. 12; no. 1; pp. 53 - 58
Main Authors Ota, Shuji, Fujigaki, Yoshihide, Tamura, Yoshifuru, Kojima, Kenichiro, Ochiai, Ryosuke, Haruyama, Terunobu, Ishihara, Masashi, Natsume, Maika, Fukasawa, Yoko, Sakamoto, Takahiko, Tanzawa, Shigeru, Usui, Ryo, Honda, Takeshi, Ichikawa, Yasuko, Watanabe, Kiyotaka, Seki, Nobuhiko
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 01.01.2019
Karger Publishers
Subjects
Antigens
Biopsy
Cancer therapies
Case Report
Case reports
Chemotherapy
Edema
Hepatitis
Internal medicine
Kidney diseases
Lung cancer
Medical diagnosis
Medical prognosis
Medicine
Nephrology
Nephrotic syndrome
Neutropenia
Oncology
Patients
Proteins
Japan
Chemotherapy
Lung cancer
Nephrotic syndrome
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Summary:We encountered a case of primary lung cancer complicated with membranous nephropathy as primary nephrotic syndrome. Because treatment approaches vary greatly for primary and secondary nephrotic syndrome, a renal biopsy was performed for diagnosis. Much time was required to make a definitive diagnosis of primary nephrotic syndrome, as opposed to paraneoplastic nephrotic syndrome. Consequently, the subsequent chemotherapy was ineffective and caused significant toxicity due to reduced performance status (PS) and progression of hypoalbuminemia. Therefore, it is imperative that a diagnosis be made and treatment be initiated without delay before PS declines and hypoalbuminemia progresses.
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ISSN:1662-6575
1662-6575
DOI:10.1159/000493851