Sickle-cell disease in Malawian children is associated with restrictive spirometry: a cross-sectional survey
BACKGROUND: A proportion of children with sickle-cell disease (SCD) demonstrate clinical findings consistent with the diagnosis of asthma. These children are at increased risk of complications, including acute chest syndrome.OBJECTIVE: To assess lung function and symptoms of asthma in children with...
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Published in | The international journal of tuberculosis and lung disease Vol. 17; no. 9; pp. 1235 - 1238 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Paris, France
International Union Against Tuberculosis and Lung Disease
01.09.2013
International Union against Tuberculosis and Lung Disease |
Subjects | |
Online Access | Get full text |
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Summary: | BACKGROUND: A proportion of children with sickle-cell disease (SCD) demonstrate clinical findings consistent with the diagnosis of asthma. These children are at increased risk of complications, including acute chest syndrome.OBJECTIVE: To assess lung function and symptoms of asthma
in children with SCD in Blantyre, Malawi.DESIGN: Twenty-five children aged 7-16 years with electrophoretically confirmed SCD were recruited to undergo spirometry and questionnaire screening of asthma symptoms. Forced expiratory volume in 1 second (FEV1), forced vital capacity
(FVC) and FEV1/FVC ratio were compared with local and international reference ranges. Symptoms were assessed using the International Study of Asthma and Allergies in Childhood questionnaire.RESULTS: Mean spirometric indices, represented as Z-scores derived from international
reference ranges, were low: FEV1 −1.64 (95%CI −2.04 to −1.23), FVC −1.49 (95%CI −1.90 to −1.09), FEV1/FVC −0.39 (95%CI −0.76 to −0.03). Comparison with local reference ranges, represented as percentage of predicted
value, revealed similar impairments: FEV1 86.9 (95%CI 81.1 to 92.7), FVC 89.0 (95%CI 83.5 to 94.4), FEV1/FVC ratio 97.7 (95%CI 95.4 to 99.9). The prevalence of wheeze was 16.7%.CONCLUSION: We present spirometric abnormalities suggestive of restrictive lung disease
with no evidence of obstructive defects or increased prevalence of wheeze. |
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Bibliography: | 1027-3719(20130901)17:9L.1235;1- (R) Medicine - General ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 Acquisition of data, questionnaire design. Conception and acquisition of data. Conception, design, acquisition of data, analysis and interpretation of data, drafting of article. |
ISSN: | 1027-3719 1815-7920 |
DOI: | 10.5588/ijtld.12.0965 |