Pharmacogenomics of CYP2D6: Molecular Genetics, Interethnic Differences and Clinical Importance

CYP2D6 has received intense attention since the beginning of the pharmacogenetic era in the 1970s. This is because of its involvement in the metabolism of more than 25% of the marketed drugs, the large geographical and inter-ethnic differences in the genetic polymorphism and possible drug-induced to...

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Published inDRUG METABOLISM AND PHARMACOKINETICS Vol. 27; no. 1; pp. 55 - 67
Main Authors Teh, Lay Kek, Bertilsson, Leif
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 2012
Japanese Society for the Study of Xenobiotics
Subjects
Biotransformation
clinical implication
CYP2D6 polymorphism
Cytochrome P-450 CYP2D6 - genetics
Cytochrome P-450 CYP2D6 - metabolism
Drug Interactions
Genetic Predisposition to Disease
Humans
interethnic differences
Pharmacogenetics - methods
Pharmacokinetics
Polymorphism, Genetic
clinical implication
interethnic differences
CYP2D6 polymorphism
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Summary:CYP2D6 has received intense attention since the beginning of the pharmacogenetic era in the 1970s. This is because of its involvement in the metabolism of more than 25% of the marketed drugs, the large geographical and inter-ethnic differences in the genetic polymorphism and possible drug-induced toxicity. Many interesting reviews have been published on CYP2D6 and this review aims to reinstate the importance of the genetic polymorphism of CYP2D6 in different populations as well as some clinical implications and important drug interactions.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Review-3
content type line 23
ISSN:1347-4367
1880-0920
1880-0920
DOI:10.2133/dmpk.DMPK-11-RV-121