Antithetical Effects of MicroRNA Molecules in Tuberculosis Pathogenesis

[1],[2] On the other hand, recent studies have revealed that infectious disease can induce microRNA (miRNA) molecule responses, for example, MiR-155 in Helicobacter pylori infection, let-7 family in Salmonella infection, and particularly, MiR-29 in mice infected with BCG vaccine. Overall, they impre...

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Published inAdvanced biomedical research Vol. 8; no. 1; p. 3
Main Authors Keikha, Masoud, Karbalaei, Mohsen
Format Journal Article
LanguageEnglish
Published India Medknow Publications and Media Pvt. Ltd 01.01.2019
Medknow Publications & Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
Wolters Kluwer Medknow Publications
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Summary:[1],[2] On the other hand, recent studies have revealed that infectious disease can induce microRNA (miRNA) molecule responses, for example, MiR-155 in Helicobacter pylori infection, let-7 family in Salmonella infection, and particularly, MiR-29 in mice infected with BCG vaccine. Overall, they impress various cell functions including cell proliferation and differentiation, DNA repair system, DNA modification (e.g. DNA methylation), apoptosis, and particularly, anti-inflammatory signaling pathways. PKA has pivotal roles on the cellular immune system, for example, activation of mitogen-activated protein kinase and induction of apoptotic pathway in MTB-infected macrophages.
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ISSN:2277-9175
2277-9175
DOI:10.4103/abr.abr_217_18