Subclinical thyroid disease

Subclinical thyroid diseases—subclinical hyperthyroidism and subclinical hypothyroidism—are common clinical entities that encompass mild degrees of thyroid dysfunction. The clinical significance of mild thyroid overactivity and underactivity is uncertain, which has led to controversy over the approp...

Full description

Saved in:
Bibliographic Details
Published inThe Lancet (British edition) Vol. 379; no. 9821; pp. 1142 - 1154
Main Authors Cooper, David S, Prof, Biondi, Bernadette, Prof
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier Ltd 24.03.2012
Elsevier
Elsevier Limited
Subjects
Atrial Fibrillation - epidemiology
Biological and medical sciences
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - physiopathology
Comorbidity
Diagnosis, Differential
Disease Progression
Dyslipidemias - epidemiology
Dyslipidemias - physiopathology
Endocrinopathies
Epidemiology
Female
General aspects
Hormones
Humans
hyperthyroidism
Hyperthyroidism - blood
Hyperthyroidism - diagnosis
Hyperthyroidism - epidemiology
hypothyroidism
Hypothyroidism - blood
Hypothyroidism - diagnosis
Hypothyroidism - epidemiology
Internal Medicine
Medical sciences
Morbidity
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Nutrition Surveys
Older people
Osteoporosis - epidemiology
Pregnancy
Pregnancy Complications - epidemiology
Quality of Life
risk
Thyroid
Thyroid gland
Thyroid Hormones - physiology
Thyroid. Thyroid axis (diseases)
Thyroiditis - diagnosis
thyrotropin
Thyrotropin - blood
Thyroxine - administration & dosage
United States - epidemiology
Womens health
United States
Endocrinopathy
Medicine
Asymptomatic
Thyroid diseases
Online AccessGet full text

Cover

More Information
Summary:Subclinical thyroid diseases—subclinical hyperthyroidism and subclinical hypothyroidism—are common clinical entities that encompass mild degrees of thyroid dysfunction. The clinical significance of mild thyroid overactivity and underactivity is uncertain, which has led to controversy over the appropriateness of diagnostic testing and possible treatment. In this Seminar, we discuss the definition, epidemiology, differential diagnoses, risks of progression to overt thyroid disease, potential effects on various health outcomes, and management of subclinical hyperthyroidism and subclinical hypothyroidism. Treatment recommendations are based on the degree to which thyroid-stimulating hormone concentrations have deviated from normal and underlying comorbidities. Large-scale randomised trials are urgently needed to inform how to best care for individuals with subclinical thyroid disease.
Bibliography:http://dx.doi.org/10.1016/S0140-6736(11)60276-6
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Feature-3
ObjectType-Review-1
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(11)60276-6