Fertility information needs and concerns post-treatment contribute to lowered quality of life among young adult female cancer survivors
Background Cancer treatment may lead to premature menopause and infertility. Young adult female cancer survivors (YAFCS) are often concerned about their fertility and future family-building options, but research is limited on how concerns may affect more general quality of life (QOL) domains. This s...
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Published in | Supportive care in cancer Vol. 26; no. 7; pp. 2209 - 2215 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.07.2018
Springer Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Background
Cancer treatment may lead to premature menopause and infertility. Young adult female cancer survivors (YAFCS) are often concerned about their fertility and future family-building options, but research is limited on how concerns may affect more general quality of life (QOL) domains. This study examined how fertility factors relate to QOL among YAFCS who received gonadotoxic therapy.
Method
A national sample of YAFCS completed an online, anonymous survey. The survey included investigator-designed questions about perceived fertility information needs (five items; Cronbach’s
α
= .83) and general QOL (four items;
α
= .89), the Reproductive Concerns after Cancer Scale (RCACS) and Decisional Conflict Scale (DCS). Analyses included Pearson’s correlation,
t
tests, and stepwise regression.
Results
Participants (
N
= 314) were an average of 30 years old (SD = 4.1) and 5 years (SD = 5.4) post-treatment; 31% reported being infertile and 19% had undergone fertility preservation (FP). Overall, QOL was relatively high (
M
= 7.3, SD = 1.9, range 0–10) and did not vary by fertility status (
t
[272] = .743,
p
= .46), prior FP (
t
[273] = .53,
p
= .55) or sociodemographic/clinical factors (
p
’s > .05) except socioeconomic indicators (
p
’s < .05).In separate models, greater unmet fertility information needs (
β
= − .19,
p
= .004) and, among fertile women, greater reproductive concerns (
β
= − .26,
p
= .001) related to lower QOL. Among fertile women without prior FP, greater decisional distress about future FP related to lower QOL (
β
= − .19,
p
= .03).
Conclusions
These preliminary findings suggest that unaddressed fertility information needs, concerns, and decision distress may affect general QOL among post-treatment YAFCS who hope to have children in the future. Future work should identify ways to optimally incorporate fertility counseling and support resources into survivorship care programs, including referrals to reproductive specialists as appropriate. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0941-4355 1433-7339 |
DOI: | 10.1007/s00520-017-4006-z |