[11C]Carbon monoxide: advances in production and application to PET radiotracer development over the past 15 years

[ 11 C]Carbon monoxide is an appealing synthon for introducing carbon-11 at a carbonyl position (C=O) in a wide variety of chemotypes (e.g., amides, ketones, acids, esters, and ureas). The prevalence of the carbonyl group in drug molecules and the present-day broad versatility of carbonylation react...

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Published inEJNMMI radiopharmacy and chemistry Vol. 4; no. 1; pp. 1 - 31
Main Authors Taddei, Carlotta, Pike, Victor W.
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 18.09.2019
Springer Nature B.V
SpringerOpen
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Abstract [ 11 C]Carbon monoxide is an appealing synthon for introducing carbon-11 at a carbonyl position (C=O) in a wide variety of chemotypes (e.g., amides, ketones, acids, esters, and ureas). The prevalence of the carbonyl group in drug molecules and the present-day broad versatility of carbonylation reactions have led to an upsurge in the production of this synthon and in its application to PET radiotracer development. This review focuses on the major advances of the past 15 years.
AbstractList Abstract [11C]Carbon monoxide is an appealing synthon for introducing carbon-11 at a carbonyl position (C=O) in a wide variety of chemotypes (e.g., amides, ketones, acids, esters, and ureas). The prevalence of the carbonyl group in drug molecules and the present-day broad versatility of carbonylation reactions have led to an upsurge in the production of this synthon and in its application to PET radiotracer development. This review focuses on the major advances of the past 15 years.
[ 11 C]Carbon monoxide is an appealing synthon for introducing carbon-11 at a carbonyl position (C=O) in a wide variety of chemotypes (e.g., amides, ketones, acids, esters, and ureas). The prevalence of the carbonyl group in drug molecules and the present-day broad versatility of carbonylation reactions have led to an upsurge in the production of this synthon and in its application to PET radiotracer development. This review focuses on the major advances of the past 15 years.
[11C]Carbon monoxide is an appealing synthon for introducing carbon-11 at a carbonyl position (C=O) in a wide variety of chemotypes (e.g., amides, ketones, acids, esters, and ureas). The prevalence of the carbonyl group in drug molecules and the present-day broad versatility of carbonylation reactions have led to an upsurge in the production of this synthon and in its application to PET radiotracer development. This review focuses on the major advances of the past 15 years.
ArticleNumber 25
Author Pike, Victor W.
Taddei, Carlotta
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  organization: Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health
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  givenname: Victor W.
  surname: Pike
  fullname: Pike, Victor W.
  organization: Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health
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Issue 1
Keywords Carbonylation
Carbon-11
Carbon monoxide
Radiotracer
PET
Radiochemistry
Language English
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Snippet [ 11 C]Carbon monoxide is an appealing synthon for introducing carbon-11 at a carbonyl position (C=O) in a wide variety of chemotypes (e.g., amides, ketones,...
[11C]Carbon monoxide is an appealing synthon for introducing carbon-11 at a carbonyl position (C=O) in a wide variety of chemotypes (e.g., amides, ketones,...
Abstract [11C]Carbon monoxide is an appealing synthon for introducing carbon-11 at a carbonyl position (C=O) in a wide variety of chemotypes (e.g., amides,...
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SubjectTerms Amides
Carbon monoxide
Carbon-11
Carbonyl compounds
Carbonylation
Esters
Imaging
Medicine
Medicine & Public Health
Molecular Medicine
Nuclear Chemistry
Nuclear Medicine
PET
Pharmacotherapy
Radioactive tracers
Radiochemistry
Radiology
Radiotracer
Review
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Title [11C]Carbon monoxide: advances in production and application to PET radiotracer development over the past 15 years
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