[11C]Carbon monoxide: advances in production and application to PET radiotracer development over the past 15 years
[ 11 C]Carbon monoxide is an appealing synthon for introducing carbon-11 at a carbonyl position (C=O) in a wide variety of chemotypes (e.g., amides, ketones, acids, esters, and ureas). The prevalence of the carbonyl group in drug molecules and the present-day broad versatility of carbonylation react...
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Published in | EJNMMI radiopharmacy and chemistry Vol. 4; no. 1; pp. 1 - 31 |
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Main Authors | , |
Format | Journal Article |
Language | English |
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Springer International Publishing
18.09.2019
Springer Nature B.V SpringerOpen |
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Abstract | [
11
C]Carbon monoxide is an appealing synthon for introducing carbon-11 at a carbonyl position (C=O) in a wide variety of chemotypes (e.g., amides, ketones, acids, esters, and ureas). The prevalence of the carbonyl group in drug molecules and the present-day broad versatility of carbonylation reactions have led to an upsurge in the production of this synthon and in its application to PET radiotracer development. This review focuses on the major advances of the past 15 years. |
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AbstractList | Abstract [11C]Carbon monoxide is an appealing synthon for introducing carbon-11 at a carbonyl position (C=O) in a wide variety of chemotypes (e.g., amides, ketones, acids, esters, and ureas). The prevalence of the carbonyl group in drug molecules and the present-day broad versatility of carbonylation reactions have led to an upsurge in the production of this synthon and in its application to PET radiotracer development. This review focuses on the major advances of the past 15 years. [ 11 C]Carbon monoxide is an appealing synthon for introducing carbon-11 at a carbonyl position (C=O) in a wide variety of chemotypes (e.g., amides, ketones, acids, esters, and ureas). The prevalence of the carbonyl group in drug molecules and the present-day broad versatility of carbonylation reactions have led to an upsurge in the production of this synthon and in its application to PET radiotracer development. This review focuses on the major advances of the past 15 years. [11C]Carbon monoxide is an appealing synthon for introducing carbon-11 at a carbonyl position (C=O) in a wide variety of chemotypes (e.g., amides, ketones, acids, esters, and ureas). The prevalence of the carbonyl group in drug molecules and the present-day broad versatility of carbonylation reactions have led to an upsurge in the production of this synthon and in its application to PET radiotracer development. This review focuses on the major advances of the past 15 years. |
ArticleNumber | 25 |
Author | Pike, Victor W. Taddei, Carlotta |
Author_xml | – sequence: 1 givenname: Carlotta orcidid: 0000-0002-2271-2127 surname: Taddei fullname: Taddei, Carlotta email: carlotta.taddei@nih.gov organization: Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health – sequence: 2 givenname: Victor W. surname: Pike fullname: Pike, Victor W. organization: Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health |
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C]Carbon monoxide is an appealing synthon for introducing carbon-11 at a carbonyl position (C=O) in a wide variety of chemotypes (e.g., amides, ketones,... [11C]Carbon monoxide is an appealing synthon for introducing carbon-11 at a carbonyl position (C=O) in a wide variety of chemotypes (e.g., amides, ketones,... Abstract [11C]Carbon monoxide is an appealing synthon for introducing carbon-11 at a carbonyl position (C=O) in a wide variety of chemotypes (e.g., amides,... |
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SubjectTerms | Amides Carbon monoxide Carbon-11 Carbonyl compounds Carbonylation Esters Imaging Medicine Medicine & Public Health Molecular Medicine Nuclear Chemistry Nuclear Medicine PET Pharmacotherapy Radioactive tracers Radiochemistry Radiology Radiotracer Review |
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Title | [11C]Carbon monoxide: advances in production and application to PET radiotracer development over the past 15 years |
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