[11C]Carbon monoxide: advances in production and application to PET radiotracer development over the past 15 years

[ 11 C]Carbon monoxide is an appealing synthon for introducing carbon-11 at a carbonyl position (C=O) in a wide variety of chemotypes (e.g., amides, ketones, acids, esters, and ureas). The prevalence of the carbonyl group in drug molecules and the present-day broad versatility of carbonylation react...

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Published inEJNMMI radiopharmacy and chemistry Vol. 4; no. 1; pp. 1 - 31
Main Authors Taddei, Carlotta, Pike, Victor W.
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 18.09.2019
Springer Nature B.V
SpringerOpen
Subjects
Amides
Carbon monoxide
Carbon-11
Carbonyl compounds
Carbonylation
Esters
Imaging
Medicine
Medicine & Public Health
Molecular Medicine
Nuclear Chemistry
Nuclear Medicine
PET
Pharmacotherapy
Radioactive tracers
Radiochemistry
Radiology
Radiotracer
Review
Carbonylation
Carbon-11
Carbon monoxide
Radiotracer
PET
Radiochemistry
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Summary:[ 11 C]Carbon monoxide is an appealing synthon for introducing carbon-11 at a carbonyl position (C=O) in a wide variety of chemotypes (e.g., amides, ketones, acids, esters, and ureas). The prevalence of the carbonyl group in drug molecules and the present-day broad versatility of carbonylation reactions have led to an upsurge in the production of this synthon and in its application to PET radiotracer development. This review focuses on the major advances of the past 15 years.
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ISSN:2365-421X
2365-421X
DOI:10.1186/s41181-019-0073-4