Selective cytotoxic eremophilane-type sesquiterpenes from Penicillium citreonigrum
One new eremophilane-type sesquiterpene (1, citreopenin) was isolated from Penicillium citreonigrum (HQ738282), and the structure was elucidated by a combination of spectroscopic data interpretation and single-crystal X-ray diffraction analysis using Cu Kα radiation (CCDC 1030588). Compound 1 showed...
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Published in | Journal of asian natural products research Vol. 17; no. 12; pp. 1239 - 1244 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
ABINGDON
Taylor & Francis
02.12.2015
Taylor & Francis Ltd |
Subjects | |
Online Access | Get full text |
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Summary: | One new eremophilane-type sesquiterpene (1, citreopenin) was isolated from Penicillium citreonigrum (HQ738282), and the structure was elucidated by a combination of spectroscopic data interpretation and single-crystal X-ray diffraction analysis using Cu Kα radiation (CCDC 1030588). Compound 1 showed weak activity against KB-VIN (IC
50
= 11.0 ± 0.156 μM), while the known compound 3 exhibited selective cytotoxicity against MDA-MB-231 triple-negative breast cancer (TNBC) (IC
50
= 5.42 ± 0.167 μM). |
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Bibliography: | NIH RePORTER SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1028-6020 1477-2213 1477-2213 |
DOI: | 10.1080/10286020.2015.1115020 |