Selective cytotoxic eremophilane-type sesquiterpenes from Penicillium citreonigrum

One new eremophilane-type sesquiterpene (1, citreopenin) was isolated from Penicillium citreonigrum (HQ738282), and the structure was elucidated by a combination of spectroscopic data interpretation and single-crystal X-ray diffraction analysis using Cu Kα radiation (CCDC 1030588). Compound 1 showed...

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Published inJournal of asian natural products research Vol. 17; no. 12; pp. 1239 - 1244
Main Authors Yuan, Wei-Hua, Goto, Masuo, Hsieh, Kan-Yen, Yuan, Bo, Zhao, Yu, Morris-Natschke, Susan. L, Lee, Kuo-Hsiung
Format Journal Article
LanguageEnglish
Published ABINGDON Taylor & Francis 02.12.2015
Taylor & Francis Ltd
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Summary:One new eremophilane-type sesquiterpene (1, citreopenin) was isolated from Penicillium citreonigrum (HQ738282), and the structure was elucidated by a combination of spectroscopic data interpretation and single-crystal X-ray diffraction analysis using Cu Kα radiation (CCDC 1030588). Compound 1 showed weak activity against KB-VIN (IC 50  = 11.0 ± 0.156 μM), while the known compound 3 exhibited selective cytotoxicity against MDA-MB-231 triple-negative breast cancer (TNBC) (IC 50  = 5.42 ± 0.167 μM).
Bibliography:NIH RePORTER
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ISSN:1028-6020
1477-2213
1477-2213
DOI:10.1080/10286020.2015.1115020