Multiple functions of hypoxia-regulated miR-210 in cancer

• Published in: Journal of experimental & clinical cancer research Vol. 33; no. 1; p. 50
• Main Authors: Qin, Qin, Furong, Wei, Baosheng, Li
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 09.06.2014; BioMed Central
• Subjects: Angiogenesis; Apoptosis; Cancer; Cell cycle; Cell death; Cell growth; Cell Hypoxia; Cell Proliferation; DNA Repair; Gene expression; Gene Expression Regulation, Neoplastic; Genes; Genetic aspects; Genetic transcription; Health aspects; Hospitals; Humans; Hypoxia; Medical prognosis; MicroRNAs - genetics; MicroRNAs - metabolism; Mitochondria - metabolism; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Neovascularization, Pathologic - genetics; Oncogenes; Oncology, Experimental; Physiological aspects; Proteins; Pulmonary arteries; Review; Smooth muscle; Studies; Tumorigenesis
• ISSN: 1756-9966; 0392-9078; 1756-9966
• DOI: 10.1186/1756-9966-33-50

MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression post-transcriptionally. miRNAs can be induced by a variety of stresses such as hypoxia, and are involved in diverse biological processes including differentiation, cell proliferation, cell death, and tumorigenesis. Hypoxia, a common feature of tumor microenvironment, can induce a number of miRNAs expression. miRNA-210 (miR-210) is one of the hypoxia-regulated-miRNAs, which has been investigated extensively in cancer. However, paradoxically opposing results were documented regarding whether it is an oncogene or a tumor suppressor, and whether it is a positive or negative prognostic biomarker. In the present review, we focus on the following investigations of miR-210: 1) its functions of as an oncogene, 2) its functions as a tumor suppressor, 3) its functions in mitochondrial metabolism, and finally, the diagnostic and prognostic value of miR-210 in cancer researches.