Regulation of cross-talk in yeast MAPK signaling pathways

• Published in: Current opinion in microbiology Vol. 13; no. 6; pp. 677 - 683
• Main Author: Saito, Haruo
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.12.2010; Elsevier
• Subjects: Biological and medical sciences; Extracellular Signal-Regulated MAP Kinases - metabolism; Fundamental and applied biological sciences. Psychology; Fungal Proteins - metabolism; Gene Expression Regulation, Fungal; Microbiology; Pathology; Regulon; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae - physiology; Signal Transduction; Mitogen-activated protein kinase; Yeast; Review; Enzyme; Transferases
• ISSN: 1369-5274; 1879-0364; 1879-0364
• DOI: 10.1016/j.mib.2010.09.001

MAP kinase (MAPK) modules are conserved three-kinase cascades that serve central roles in intracellular signal transduction in eukaryotic cells. MAPK pathways of different inputs and outputs use overlapping sets of signaling components. In yeast, for example, three MAPK pathways (pheromone response, filamentous growth response, and osmostress adaptation) all use the same Ste11 MAPK kinase kinase (MAPKKK). How undesirable leakage of signal, or cross-talk, is prevented between these pathways has been a subject of intensive study. This review discusses recent findings from yeast that indicate that there is no single mechanism, but that a combination of four general strategies (docking interactions, scaffold proteins, cross-pathway inhibition, and kinetic insulation) are utilized for the prevention of cross-talk between any two MAPK modules.