Clinical practice guidelines for congenital hyperinsulinism

• Published in: Clinical Pediatric Endocrinology Vol. 26; no. 3; pp. 127 - 152
• Main Authors: Yorifuji, Tohru, Horikawa, Reiko, Hasegawa, Tomonobu, Adachi, Masanori, Soneda, Shun, Minagawa, Masanori, Ida, Shinobu, Yonekura, Takeo, Kinoshita, Yoshiaki, Kanamori, Yutaka, Kitagawa, Hiroaki, Shinkai, Masato, Sasaki, Hideyuki, Nio, Masaki, (on behalf of The Japanese Society for Pediatric Endocrinology and The Japanese Society of Pediatric Surgeons)
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society for Pediatric Endocrinology 01.01.2017
• Subjects: congenital hyperinsulinism; guidelines; hypoglycemia; Original; congenital hyperinsulinism; guidelines; hypoglycemia
• ISSN: 0918-5739; 1347-7358
• DOI: 10.1297/cpe.26.127

Congenital hyperinsulinism is a rare condition, and following recent advances in diagnosis and treatment, it was considered necessary to formulate evidence-based clinical practice guidelines reflecting the most recent progress, to guide the practice of neonatologists, pediatric endocrinologists, general pediatricians, and pediatric surgeons. These guidelines cover a range of aspects, including general features of congenital hyperinsulinism, diagnostic criteria and tools for diagnosis, first- and second-line medical treatment, criteria for and details of surgical treatment, and future perspectives. These guidelines were generated as a collaborative effort between The Japanese Society for Pediatric Endocrinology and The Japanese Society of Pediatric Surgeons, and followed the official procedures of guideline generation to identify important clinical questions, perform a systematic literature review (April 2016), assess the evidence level of each paper, formulate the guidelines, and obtain public comments.