Exosomal miR-23b from bone marrow mesenchymal stem cells alleviates oxidative stress and pyroptosis after intracerebral hemorrhage

• Published in: Neural regeneration research Vol. 18; no. 3; pp. 560 - 567
• Main Authors: Hu, Liu-Ting, Wang, Bing-Yang, Fan, Yu-Hua, He, Zhi-Yi, Zheng, Wen-Xu
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.03.2023; Medknow Publications & Media Pvt. Ltd; Department of Neurology,The First Affiliated Hospital,Sun Yat-Sen University,Guangzhou,Guangdong Province,China; Department of Neurology,The First Affiliated Hospital of China Medical University,Shenyang,Liaoning Province,China%Department of Neurology,The First Affiliated Hospital of China Medical University,Shenyang,Liaoning Province,China%Department of Neurology,The First Affiliated Hospital,Sun Yat-Sen University,Guangzhou,Guangdong Province,China%Geriatric Department of Dalian Friendship Hospital,Dalian,Liaoning Province,China; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: Bone marrow; bone marrow mesenchymal stem cells; exosomal mirnas; intracerebral hemorrhage; mir-23b; neuroinflammation; nlrp3 inflammasome; nrf2; oxidative stress; pten; pyroptosis; Oxidative stress; intracerebral hemorrhage; pyroptosis; Nrf2; neuroinflammation; miR-23b; PTEN; NLRP3 inflammasome; bone marrow mesenchymal stem cells; oxidative stress; exosomal miRNAs

Our previous studies showed that miR-23b was downregulated in patients with intracerebral hemorrhage (ICH). This indicates that miR-23b may be closely related to the patho-physiological mechanism of ICH, but this hypothesis lacks direct evidence. In this study, we established rat models of ICH by in...