Inflammation and retinal degenerative diseases

Vision is an ability that depends on the precise structure and functioning of the retina. Any kind of stress or injury can disrupt the retinal architecture and leads to vision impairment, vision loss, and blindness. Immune system and immune response function maintain homeostasis in the microenvironm...

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Bibliographic Details
Published inNeural regeneration research Vol. 18; no. 3; pp. 513 - 518
Main Authors Kaur, Geetika, Singh, Nikhlesh
Format Journal Article
LanguageEnglish
Published India Wolters Kluwer India Pvt. Ltd 01.03.2023
Medknow Publications & Media Pvt. Ltd
Integrative Biosciences Center,Wayne State University,Detroit,MI,USA
Department of Ophthalmology,Visual and Anatomical Sciences,Wayne State University School of Medicine,Detroit,MI,USA
Wolters Kluwer - Medknow
Wolters Kluwer Medknow Publications
Subjects
age-related macular degeneration; diabetic retinopathy; glaucoma; retina; retinal degeneration; retinitis pigmentosa
Diabetic retinopathy
Inflammation
Review
retinitis pigmentosa
retinal degeneration
diabetic retinopathy
retina
age-related macular degeneration
glaucoma
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Summary:Vision is an ability that depends on the precise structure and functioning of the retina. Any kind of stress or injury can disrupt the retinal architecture and leads to vision impairment, vision loss, and blindness. Immune system and immune response function maintain homeostasis in the microenvironment. Several genetic, metabolic, and environmental factors may alter retinal homeostasis, and these events may initiate various inflammatory cascades. The prolonged inflammatory state may contribute to the initiation and development of retinal disorders such as glaucoma, age-related macular degeneration, diabetic retinopathy, and retinitis pigmentosa, which pose a threat to vision. In the current review, we attempted to provide sufficient evidence on the role of inflammation in these retinal disorders. Moreover, this review paves the way to focus on therapeutic targets of the disease, which are found to be promising.
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Author contributions: GK and NKS designed the concept, wrote and edited the manuscript. GK prepared the tables. NKS supervised the manuscript and acquired the funding. Both authors approved the final version of the manuscript.
ISSN:1673-5374
1876-7958
DOI:10.4103/1673-5374.350192